5lr1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5lr1 is ~~ON HOLD until Paper Publication~~

==CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003498614A.==

~~Authors~~: ~~VALLEE~~, F., ~~DUPUY~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5lr1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LR1 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LR1 FirstGlance].

~~Description~~: ~~CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003498614A~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=72Y:4-chloranyl-7-[(4-chloranyl-3,5-dimethyl-pyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-2-amine'>72Y</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

[[Category: ~~Dupuy~~, A]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lr1 OCA], [http://pdbe.org/5lr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lr1 RCSB], [http://www.ebi.ac.uk/pdbsum/5lr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lr1 ProSAT]</td></tr>

[[Category: ~~Vallee~~, F]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Human]]

[[Category: DUPUY, A]]

[[Category: VALLEE, F]]

[[Category: Chaperone protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5lr1 is ON HOLD  until Paper Publication
+==CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003498614A.==
+<StructureSection load='5lr1' size='340' side='right' caption='[[5lr1]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
-Authors: VALLEE, F., DUPUY, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5lr1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LR1 FirstGlance]. <br>
-Description: CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003498614A.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=72Y:4-chloranyl-7-[(4-chloranyl-3,5-dimethyl-pyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-2-amine'>72Y</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-[[Category: Dupuy, A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lr1 OCA], [http://pdbe.org/5lr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lr1 RCSB], [http://www.ebi.ac.uk/pdbsum/5lr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lr1 ProSAT]</span></td></tr>
-[[Category: Vallee, F]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Human]]
+[[Category: DUPUY, A]]
+[[Category: VALLEE, F]]
+[[Category: Chaperone protein]]