5lru: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5lru is ~~ON HOLD~~

==Structure of Cezanne/OTUD7B OTU domain==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5lru]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LRU OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LRU FirstGlance].

~~Description~~:

</td></tr><tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lru OCA], [http://pdbe.org/5lru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lru RCSB], [http://www.ebi.ac.uk/pdbsum/5lru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lru ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/OTU7B_HUMAN OTU7B_HUMAN]] Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.<ref>PMID:11463333</ref> <ref>PMID:12682062</ref> <ref>PMID:18178551</ref> <ref>PMID:20622874</ref> <ref>PMID:22179831</ref> <ref>PMID:23827681</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Ubiquitinyl hydrolase 1]]

[[Category: Akutsu, M]]

[[Category: Burke, J E]]

[[Category: Elliott, P R]]

[[Category: Freund, S M.V]]

[[Category: Gersch, M]]

[[Category: Geurink, P P]]

[[Category: Kawasaki, M]]

[[Category: Komander, D]]

[[Category: Kulathu, Y]]

[[Category: Maslen, S L]]

[[Category: Mevissen, T E.T]]

[[Category: Mulder, M P.C]]

[[Category: Oualid, F El]]

[[Category: Ovaa, H]]

[[Category: Tol, B D.M van]]

[[Category: Deubiquitinase]]

[[Category: Hydrolase]]

[[Category: Otu domain]]

[[Category: Protease]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5lru is ON HOLD
+==Structure of Cezanne/OTUD7B OTU domain==
+<StructureSection load='5lru' size='340' side='right' caption='[[5lru]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5lru]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LRU FirstGlance]. <br>
-Description:
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lru OCA], [http://pdbe.org/5lru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lru RCSB], [http://www.ebi.ac.uk/pdbsum/5lru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lru ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/OTU7B_HUMAN OTU7B_HUMAN]] Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.<ref>PMID:11463333</ref> <ref>PMID:12682062</ref> <ref>PMID:18178551</ref> <ref>PMID:20622874</ref> <ref>PMID:22179831</ref> <ref>PMID:23827681</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ubiquitinyl hydrolase 1]]
+[[Category: Akutsu, M]]
+[[Category: Burke, J E]]
+[[Category: Elliott, P R]]
+[[Category: Freund, S M.V]]
+[[Category: Gersch, M]]
+[[Category: Geurink, P P]]
+[[Category: Kawasaki, M]]
+[[Category: Komander, D]]
+[[Category: Kulathu, Y]]
+[[Category: Maslen, S L]]
+[[Category: Mevissen, T E.T]]
+[[Category: Mulder, M P.C]]
+[[Category: Oualid, F El]]
+[[Category: Ovaa, H]]
+[[Category: Tol, B D.M van]]
+[[Category: Deubiquitinase]]
+[[Category: Hydrolase]]
+[[Category: Otu domain]]
+[[Category: Protease]]