5svu: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5svu is ~~ON HOLD~~

==Structure and kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis==

~~Authors~~: ~~Zoltowski~~, B., ~~Pudasaini~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5svu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SVU OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SVU FirstGlance].

~~Description~~: ~~Structure~~ and ~~kinetics~~ of the ~~LOV domain~~ of ~~ZEITLUPE determine its circadian function in Arabidopsis~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5svg|5svg]], [[5svv|5svv]], [[5svw|5svw]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5svu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5svu OCA], [http://pdbe.org/5svu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5svu RCSB], [http://www.ebi.ac.uk/pdbsum/5svu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5svu ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ADO1_ARATH ADO1_ARATH]] Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO1) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5, but not 'GIGANTEA', are proteolytic substrates of this ubiquitin ligase complex. Blue light enhances cooperative stabilization of 'GIGANTEA' and ADO1/ZTL, leading to amplification and sharpening of the expression profile of APRR1/TOC1. ADO1/ZTL interacts with ADO3, preventing the interaction of ADO3 with CDF1.<ref>PMID:10847686</ref> <ref>PMID:10847687</ref> <ref>PMID:10998191</ref> <ref>PMID:11260718</ref> <ref>PMID:14973171</ref> <ref>PMID:15447654</ref> <ref>PMID:16428597</ref> <ref>PMID:17704763</ref> <ref>PMID:21518052</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Pudasaini, A]]

[[Category: Zoltowski, B]]

[[Category: ~~Pudasaini, A~~]]

[[Category: Circadian clock protein]]

[[Category: Kinetic]]

[[Category: Lov]]

[[Category: Pas domain]]

[[Category: Photoreceptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5svu is ON HOLD
+==Structure and kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis==
+<StructureSection load='5svu' size='340' side='right' caption='[[5svu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-Authors: Zoltowski, B., Pudasaini, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5svu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SVU FirstGlance]. <br>
-Description: Structure and kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5svg|5svg]], [[5svv|5svv]], [[5svw|5svw]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5svu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5svu OCA], [http://pdbe.org/5svu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5svu RCSB], [http://www.ebi.ac.uk/pdbsum/5svu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5svu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ADO1_ARATH ADO1_ARATH]] Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO1) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5, but not 'GIGANTEA', are proteolytic substrates of this ubiquitin ligase complex. Blue light enhances cooperative stabilization of 'GIGANTEA' and ADO1/ZTL, leading to amplification and sharpening of the expression profile of APRR1/TOC1. ADO1/ZTL interacts with ADO3, preventing the interaction of ADO3 with CDF1.<ref>PMID:10847686</ref> <ref>PMID:10847687</ref> <ref>PMID:10998191</ref> <ref>PMID:11260718</ref> <ref>PMID:14973171</ref> <ref>PMID:15447654</ref> <ref>PMID:16428597</ref> <ref>PMID:17704763</ref> <ref>PMID:21518052</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Pudasaini, A]]
 [[Category: Zoltowski, B]]
-[[Category: Pudasaini, A]]
+[[Category: Circadian clock protein]]
+[[Category: Kinetic]]
+[[Category: Lov]]
+[[Category: Pas domain]]
+[[Category: Photoreceptor]]