5svv: Difference between revisions

Revision as of 19:18, 11 March 2017

Structure and kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis

Structural highlights

5svv is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	ACT, FMN, GOL
Related:	5svg, 5svu, 5svw
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ADO1_ARATH] Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO1) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5, but not 'GIGANTEA', are proteolytic substrates of this ubiquitin ligase complex. Blue light enhances cooperative stabilization of 'GIGANTEA' and ADO1/ZTL, leading to amplification and sharpening of the expression profile of APRR1/TOC1. ADO1/ZTL interacts with ADO3, preventing the interaction of ADO3 with CDF1.^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7] ^[8] ^[9]

References

↑ Somers DE, Schultz TF, Milnamow M, Kay SA. ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis. Cell. 2000 Apr 28;101(3):319-29. PMID:10847686
↑ Nelson DC, Lasswell J, Rogg LE, Cohen MA, Bartel B. FKF1, a clock-controlled gene that regulates the transition to flowering in Arabidopsis. Cell. 2000 Apr 28;101(3):331-40. PMID:10847687
↑ Kiyosue T, Wada M. LKP1 (LOV kelch protein 1): a factor involved in the regulation of flowering time in arabidopsis. Plant J. 2000 Sep;23(6):807-15. PMID:10998191
↑ Jarillo JA, Capel J, Tang RH, Yang HQ, Alonso JM, Ecker JR, Cashmore AR. An Arabidopsis circadian clock component interacts with both CRY1 and phyB. Nature. 2001 Mar 22;410(6827):487-90. PMID:11260718 doi:https://dx.doi.org/10.1038/35068589
↑ Somers DE, Kim WY, Geng R. The F-box protein ZEITLUPE confers dosage-dependent control on the circadian clock, photomorphogenesis, and flowering time. Plant Cell. 2004 Mar;16(3):769-82. Epub 2004 Feb 18. PMID:14973171 doi:https://dx.doi.org/10.1105/tpc.016808
↑ Han L, Mason M, Risseeuw EP, Crosby WL, Somers DE. Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing. Plant J. 2004 Oct;40(2):291-301. PMID:15447654 doi:https://dx.doi.org/10.1111/j.1365-313X.2004.02207.x
↑ Kevei E, Gyula P, Hall A, Kozma-Bognar L, Kim WY, Eriksson ME, Toth R, Hanano S, Feher B, Southern MM, Bastow RM, Viczian A, Hibberd V, Davis SJ, Somers DE, Nagy F, Millar AJ. Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE. Plant Physiol. 2006 Mar;140(3):933-45. Epub 2006 Jan 20. PMID:16428597 doi:https://dx.doi.org/10.1104/pp.105.074864
↑ Kim WY, Fujiwara S, Suh SS, Kim J, Kim Y, Han L, David K, Putterill J, Nam HG, Somers DE. ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light. Nature. 2007 Sep 20;449(7160):356-60. Epub 2007 Aug 19. PMID:17704763 doi:https://dx.doi.org/10.1038/nature06132
↑ Takase T, Nishiyama Y, Tanihigashi H, Ogura Y, Miyazaki Y, Yamada Y, Kiyosue T. LOV KELCH PROTEIN2 and ZEITLUPE repress Arabidopsis photoperiodic flowering under non-inductive conditions, dependent on FLAVIN-BINDING KELCH REPEAT F-BOX1. Plant J. 2011 Aug;67(4):608-21. doi: 10.1111/j.1365-313X.2011.04618.x. Epub 2011 , Jul 14. PMID:21518052 doi:https://dx.doi.org/10.1111/j.1365-313X.2011.04618.x

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OCA

[1] Somers DE, Schultz TF, Milnamow M, Kay SA. ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis. Cell. 2000 Apr 28;101(3):319-29. PMID:10847686

[2] Nelson DC, Lasswell J, Rogg LE, Cohen MA, Bartel B. FKF1, a clock-controlled gene that regulates the transition to flowering in Arabidopsis. Cell. 2000 Apr 28;101(3):331-40. PMID:10847687

[3] Kiyosue T, Wada M. LKP1 (LOV kelch protein 1): a factor involved in the regulation of flowering time in arabidopsis. Plant J. 2000 Sep;23(6):807-15. PMID:10998191

[4] Jarillo JA, Capel J, Tang RH, Yang HQ, Alonso JM, Ecker JR, Cashmore AR. An Arabidopsis circadian clock component interacts with both CRY1 and phyB. Nature. 2001 Mar 22;410(6827):487-90. PMID:11260718 doi:https://dx.doi.org/10.1038/35068589

[5] Somers DE, Kim WY, Geng R. The F-box protein ZEITLUPE confers dosage-dependent control on the circadian clock, photomorphogenesis, and flowering time. Plant Cell. 2004 Mar;16(3):769-82. Epub 2004 Feb 18. PMID:14973171 doi:https://dx.doi.org/10.1105/tpc.016808

[6] Han L, Mason M, Risseeuw EP, Crosby WL, Somers DE. Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing. Plant J. 2004 Oct;40(2):291-301. PMID:15447654 doi:https://dx.doi.org/10.1111/j.1365-313X.2004.02207.x

[7] Kevei E, Gyula P, Hall A, Kozma-Bognar L, Kim WY, Eriksson ME, Toth R, Hanano S, Feher B, Southern MM, Bastow RM, Viczian A, Hibberd V, Davis SJ, Somers DE, Nagy F, Millar AJ. Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE. Plant Physiol. 2006 Mar;140(3):933-45. Epub 2006 Jan 20. PMID:16428597 doi:https://dx.doi.org/10.1104/pp.105.074864

[8] Kim WY, Fujiwara S, Suh SS, Kim J, Kim Y, Han L, David K, Putterill J, Nam HG, Somers DE. ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light. Nature. 2007 Sep 20;449(7160):356-60. Epub 2007 Aug 19. PMID:17704763 doi:https://dx.doi.org/10.1038/nature06132

[9] Takase T, Nishiyama Y, Tanihigashi H, Ogura Y, Miyazaki Y, Yamada Y, Kiyosue T. LOV KELCH PROTEIN2 and ZEITLUPE repress Arabidopsis photoperiodic flowering under non-inductive conditions, dependent on FLAVIN-BINDING KELCH REPEAT F-BOX1. Plant J. 2011 Aug;67(4):608-21. doi: 10.1111/j.1365-313X.2011.04618.x. Epub 2011 , Jul 14. PMID:21518052 doi:https://dx.doi.org/10.1111/j.1365-313X.2011.04618.x

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5svv is ON HOLD
+==Structure and kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis==
+<StructureSection load='5svv' size='340' side='right' caption='[[5svv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors: Zoltowski, B., Pudasaini, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5svv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SVV FirstGlance]. <br>
-Description: Structure and kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5svg|5svg]], [[5svu|5svu]], [[5svw|5svw]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5svv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5svv OCA], [http://pdbe.org/5svv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5svv RCSB], [http://www.ebi.ac.uk/pdbsum/5svv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5svv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ADO1_ARATH ADO1_ARATH]] Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO1) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5, but not 'GIGANTEA', are proteolytic substrates of this ubiquitin ligase complex. Blue light enhances cooperative stabilization of 'GIGANTEA' and ADO1/ZTL, leading to amplification and sharpening of the expression profile of APRR1/TOC1. ADO1/ZTL interacts with ADO3, preventing the interaction of ADO3 with CDF1.<ref>PMID:10847686</ref> <ref>PMID:10847687</ref> <ref>PMID:10998191</ref> <ref>PMID:11260718</ref> <ref>PMID:14973171</ref> <ref>PMID:15447654</ref> <ref>PMID:16428597</ref> <ref>PMID:17704763</ref> <ref>PMID:21518052</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Pudasaini, A]]
 [[Category: Zoltowski, B]]
-[[Category: Pudasaini, A]]
+[[Category: Circadian clock protein]]
+[[Category: Kinetic]]
+[[Category: Lov]]
+[[Category: Pas domain]]
+[[Category: Photoreceptor]]

5svv: Difference between revisions

Revision as of 19:18, 11 March 2017

Structure and kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis

Structural highlights

Function

References

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