5t5g: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5t5g is ~~ON HOLD~~

==human SETD8 in complex with MS2177==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5t5g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T5G FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=75P:7-(2-AMINOETHOXY)-6-METHOXY-2-(PYRROLIDIN-1-YL)-N-[5-(PYRROLIDIN-1-YL)PENTYL]QUINAZOLIN-4-AMINE'>75P</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5g OCA], [http://pdbe.org/5t5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t5g RCSB], [http://www.ebi.ac.uk/pdbsum/5t5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5g ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KMT5A_HUMAN KMT5A_HUMAN]] Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.<ref>PMID:12086618</ref> <ref>PMID:12121615</ref> <ref>PMID:15200950</ref> <ref>PMID:15933069</ref> <ref>PMID:15933070</ref> <ref>PMID:16517599</ref> <ref>PMID:17707234</ref> <ref>PMID:23478445</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arrowsmith, C H]]

[[Category: Babault, N]]

[[Category: Bountra, C]]

[[Category: Brown, P J]]

[[Category: Butler, K V]]

[[Category: Edwards, A M]]

[[Category: Jin, J]]

[[Category: Ma, A]]

[[Category: Structural genomic]]

[[Category: Tempel, W]]

[[Category: Yu, W]]

[[Category: Sgc]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5t5g is ON HOLD
+==human SETD8 in complex with MS2177==
+<StructureSection load='5t5g' size='340' side='right' caption='[[5t5g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5t5g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T5G FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=75P:7-(2-AMINOETHOXY)-6-METHOXY-2-(PYRROLIDIN-1-YL)-N-[5-(PYRROLIDIN-1-YL)PENTYL]QUINAZOLIN-4-AMINE'>75P</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5g OCA], [http://pdbe.org/5t5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t5g RCSB], [http://www.ebi.ac.uk/pdbsum/5t5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5g ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KMT5A_HUMAN KMT5A_HUMAN]] Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.<ref>PMID:12086618</ref> <ref>PMID:12121615</ref> <ref>PMID:15200950</ref> <ref>PMID:15933069</ref> <ref>PMID:15933070</ref> <ref>PMID:16517599</ref> <ref>PMID:17707234</ref> <ref>PMID:23478445</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Babault, N]]
+[[Category: Bountra, C]]
+[[Category: Brown, P J]]
+[[Category: Butler, K V]]
+[[Category: Edwards, A M]]
+[[Category: Jin, J]]
+[[Category: Ma, A]]
+[[Category: Structural genomic]]
+[[Category: Tempel, W]]
+[[Category: Yu, W]]
+[[Category: Sgc]]
+[[Category: Transferase-transferase inhibitor complex]]