Tissue factor pathway inhibitor: Difference between revisions
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<StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domain II (grey) complex with trypsin (pink) and Ca+2 ion (PDB code [[1tfx]]) comp' scene=''> | <StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domain II (grey) complex with trypsin (pink) and Ca+2 ion (PDB code [[1tfx]]) comp' scene=''> | ||
== Function == | == Function == | ||
'''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa<ref>PMID:9112630</ref>. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel β sheet followed by an α helix. Kunitz I domain inhibits VIIa coagulation factor while Kunitz II domain inhibits Xa. | |||
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
The expression of hTFPI-2 in tumors is inversely related to their malignancy<ref>PMID:18000791</ref>. TFPI inhibitors are investigated as therapeutic agents agains hemophilia<ref>PMID:27207416</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
Revision as of 10:21, 14 September 2016
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3D Structures of tissue factor pathway inhibitor
Updated on 14-September-2016
1adz – hTFPI-1 kunitz domain II (mutant) – human - NMR
1irh – hTFPI-1 kunitz domain III - NMR
1tfx – hTFPI-1 kunitz domain II + trypsin
1zr0 – hTFPI-2 kunitz domain I + trypsin
4dtg – hTFPI-1 kunitz domain II + antibody
4bqd – hTFPI-1 kunitz domain I + peptide
