5t7o: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 5t7o is ON HOLD~~

==Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE==

~~Authors: Di Pisa, F., Dello Iacono, L., Bonucci, A., Mangani, S.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5t7o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T7O OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T7O FirstGlance].

~~Description:~~ Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=THG:(6S)-5,6,7,8-TETRAHYDROFOLATE'>THG</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">Tc00.1047053509153.90 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t7o OCA], [http://pdbe.org/5t7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t7o RCSB], [http://www.ebi.ac.uk/pdbsum/5t7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t7o ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/Q4DLS1_TRYCC Q4DLS1_TRYCC]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389]

__TOC__

</StructureSection>

[[Category: Trycc]]

[[Category: Bonucci, A]]

[[Category: Iacono, L Dello]]

[[Category: Mangani, S]]

[[Category: Di Pisa, F]]

[[Category: Pisa, F Di]]

[[Category: ~~Dello Iacono, L~~]]

[[Category: Folate metabolism]]

[[Category: Oxidoreductase]]

[[Category: Transferase]]

[[Category: Trypanosoma cruzi]]

[[Category: Trypanosomatidic infection]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5t7o is ON HOLD
+==Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE==
+<StructureSection load='5t7o' size='340' side='right' caption='[[5t7o]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Di Pisa, F., Dello Iacono, L., Bonucci, A., Mangani, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5t7o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T7O FirstGlance]. <br>
-Description: Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=THG:(6S)-5,6,7,8-TETRAHYDROFOLATE'>THG</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tc00.1047053509153.90 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t7o OCA], [http://pdbe.org/5t7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t7o RCSB], [http://www.ebi.ac.uk/pdbsum/5t7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t7o ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/Q4DLS1_TRYCC Q4DLS1_TRYCC]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389]
+__TOC__
+</StructureSection>
+[[Category: Trycc]]
 [[Category: Bonucci, A]]
+[[Category: Iacono, L Dello]]
 [[Category: Mangani, S]]
-[[Category: Di Pisa, F]]
+[[Category: Pisa, F Di]]
-[[Category: Dello Iacono, L]]
+[[Category: Folate metabolism]]
+[[Category: Oxidoreductase]]
+[[Category: Transferase]]
+[[Category: Trypanosoma cruzi]]
+[[Category: Trypanosomatidic infection]]