Tissue factor pathway inhibitor: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 6: | Line 6: | ||
The expression of hTFPI-2 in tumors is inversely related to their malignancy<ref>PMID:18000791</ref>. TFPI inhibitors are investigated as therapeutic agents agains hemophilia<ref>PMID:27207418</ref>. | The expression of hTFPI-2 in tumors is inversely related to their malignancy<ref>PMID:18000791</ref>. TFPI inhibitors are investigated as therapeutic agents agains hemophilia<ref>PMID:27207418</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
In the complex of TFPI-2 and trypsin, <scene name='70/707370/Cv/2'>hydrophobic residues of TFPI-2 interact with hydrophobic patch of trypsin</scene>. An <scene name='70/707370/Cv/4'>Arg residue which is the P1 residue of TFPI-2 interacts with Asp - the S1 residue of trypsin</scene><ref>PMID:15932872</ref>. | In the complex of TFPI-2 and trypsin, <scene name='70/707370/Cv/2'>hydrophobic residues of TFPI-2 interact with hydrophobic patch of trypsin</scene>. An <scene name='70/707370/Cv/4'>Arg residue which is the P1 residue of TFPI-2 interacts with Asp - the S1 residue of trypsin</scene><ref>PMID:15932872</ref>. <scene name='70/707370/Cv/5'>Ca coordination site</scene>. Water molecules shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:58, 15 September 2016
| ||||||||||||
3D Structures of tissue factor pathway inhibitor
Updated on 15-September-2016
1adz – hTFPI-1 kunitz domain II (mutant) – human - NMR
1irh – hTFPI-1 kunitz domain III - NMR
1tfx – hTFPI-1 kunitz domain II + trypsin
1zr0 – hTFPI-2 kunitz domain I + trypsin
4dtg – hTFPI-1 kunitz domain II + antibody
4bqd – hTFPI-1 kunitz domain I + peptide
