TNF receptor-associated factor: Difference between revisions

Revision as of 08:25, 15 September 2016

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Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (grey) (PDB code 1d01)

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Updated on 15-September-2016

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 <StructureSection load='1f3v' size='340' side='right' caption='Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (grey) (PDB code [[1d01]])' scene=''>
 == Function ==
-'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response.  There are 7 known TRAF proteins.  All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>.  '''TRAF2-6''' have N-terminal RING and zinc finger motifs.  '''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK.
+'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response.  There are 7 known TRAF proteins.  All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>.  '''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs.  '''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK.  '''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>.  '''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>.
 == Structural highlights ==