Transferrin: Difference between revisions
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{{STRUCTURE_1jnf| PDB=1jnf | SIZE=400| SCENE= |right|CAPTION=Rabbit transferrin with Fe+3 (light red), carbonate and Cl- (green) ion, [[1jnf]] }} | {{STRUCTURE_1jnf| PDB=1jnf | SIZE=400| SCENE= |right|CAPTION=Rabbit transferrin with Fe+3 (light red), carbonate and Cl- (green) ion, [[1jnf]] }} | ||
== Function == | |||
'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. TF contains two lobes: at the N and C termini. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]]. | |||
== Relevance == | |||
Carbohydrate-deficient TF may help diagnose alcoholic liver disease<ref>PMID:15908327</ref>. | |||
== 3D Structures of Transferrin == | == 3D Structures of Transferrin == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
* | *Transferrin | ||
**[[1jnf]] – rTF - rabbit<br /> | **[[1jnf]] – rTF - rabbit<br /> | ||
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**[[3skp]] – hTF C terminal<br /> | **[[3skp]] – hTF C terminal<br /> | ||
* | *Apo transferrin | ||
**[[1bp5]], [[1btj]] - hTF N terminal<br /> | **[[1bp5]], [[1btj]] - hTF N terminal<br /> | ||
**[[2hau]], [[2hav]] – hTF (mutant) | **[[2hau]], [[2hav]] – hTF (mutant) | ||
* | *Ovotransferrin | ||
**[[1ovt]], [[1n04]] – cOTF + Fe+3 - chicken<br /> | **[[1ovt]], [[1n04]] – cOTF + Fe+3 - chicken<br /> | ||
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**[[1nnt]], [[1nft]], [[1iej]] – cOTF N terminal<br /> | **[[1nnt]], [[1nft]], [[1iej]] – cOTF N terminal<br /> | ||
* | *Apo ovotransferrin | ||
**[[1aov]] – dOTF<br /> | **[[1aov]] – dOTF<br /> | ||
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**[[1lfc]] – OTF residues 17-41 – bovine - NMR | **[[1lfc]] – OTF residues 17-41 – bovine - NMR | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
