5t5s: Difference between revisions
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The entry | ==A fragment of a human tRNA synthetase== | ||
<StructureSection load='5t5s' size='340' side='right' caption='[[5t5s]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5t5s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T5S FirstGlance]. <br> | |||
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine--tRNA_ligase Alanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.7 6.1.1.7] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5s OCA], [http://pdbe.org/5t5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t5s RCSB], [http://www.ebi.ac.uk/pdbsum/5t5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5s ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/SYAC_HUMAN SYAC_HUMAN]] Autosomal dominant Charcot-Marie-Tooth disease type 2N. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SYAC_HUMAN SYAC_HUMAN]] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Alanine--tRNA ligase]] | |||
[[Category: Schimmel, P]] | |||
[[Category: Sun, L]] | |||
[[Category: Translation]] | |||
[[Category: Trna synthetase]] | |||
Revision as of 18:38, 10 December 2016
A fragment of a human tRNA synthetase
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