5tb6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5tb6 ~~is ON HOLD~~

==Structure of bromodomain of CREBBP with a pyrazolo[4,3-c]pyridin fragment==

~~Authors~~: ~~Filippakopoulos, P~~., ~~Picaud~~, S., ~~Knapp~~, S., ~~von Delft~~, F., ~~Bountra~~, C., ~~Arrowsmith~~, C.H., ~~Edwards~~, A.~~, Structural Genomics Consortium (SGC)~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5tb6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TB6 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TB6 FirstGlance].

~~Description~~: ~~Structure~~ of ~~romodomain of CREBBO~~ with a ~~pyrazolo~~[4,~~3-c]pyridin fragment~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=77X:1-(3-PHENYL-1,4,6,7-TETRAHYDROPYRAZOLO[4,3-C]PYRIDIN-5-YL)PROPAN-1-ONE'>77X</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </td></tr>

[[Category: ~~Picaud, S~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tb6 OCA], [http://pdbe.org/5tb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tb6 RCSB], [http://www.ebi.ac.uk/pdbsum/5tb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tb6 ProSAT]</td></tr>

[[Category: ~~Knapp~~, S]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>

== Function ==

[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Histone acetyltransferase]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: ~~Arrowsmith~~, ~~C.H~~]]

[[Category: Delft, F von]]

[[Category: ~~Von Delft~~, F]]

[[Category: Edwards, A]]

[[Category: Filippakopoulos, P]]

[[Category: Structural ~~Genomics Consortium (~~Sgc)]]

[[Category: Knapp, S]]

[[Category: ~~Edwards, A~~]]

[[Category: Picaud, S]]

[[Category: Structural genomic]]

[[Category: Bromodomain]]

[[Category: Complex]]

[[Category: Fragment]]

[[Category: Sgc]]

[[Category: Transferase]]

[[Category: Trasnferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5tb6 is ON HOLD
+==Structure of bromodomain of CREBBP with a pyrazolo[4,3-c]pyridin fragment==
+<StructureSection load='5tb6' size='340' side='right' caption='[[5tb6]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
-Authors: Filippakopoulos, P., Picaud, S., Knapp, S., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5tb6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TB6 FirstGlance]. <br>
-Description: Structure of romodomain of CREBBO with a pyrazolo[4,3-c]pyridin fragment
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=77X:1-(3-PHENYL-1,4,6,7-TETRAHYDROPYRAZOLO[4,3-C]PYRIDIN-5-YL)PROPAN-1-ONE'>77X</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
-[[Category: Picaud, S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tb6 OCA], [http://pdbe.org/5tb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tb6 RCSB], [http://www.ebi.ac.uk/pdbsum/5tb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tb6 ProSAT]</span></td></tr>
-[[Category: Knapp, S]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.  Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Histone acetyltransferase]]
+[[Category: Arrowsmith, C H]]
 [[Category: Bountra, C]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Delft, F von]]
-[[Category: Von Delft, F]]
+[[Category: Edwards, A]]
 [[Category: Filippakopoulos, P]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Knapp, S]]
-[[Category: Edwards, A]]
+[[Category: Picaud, S]]
+[[Category: Structural genomic]]
+[[Category: Bromodomain]]
+[[Category: Complex]]
+[[Category: Fragment]]
+[[Category: Sgc]]
+[[Category: Transferase]]
+[[Category: Trasnferase]]