5kbz: Difference between revisions
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The | ==Structure of the PksA Product Template domain in complex with a phosphopantetheine mimetic== | ||
<StructureSection load='5kbz' size='340' side='right' caption='[[5kbz]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5kbz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KBZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KBZ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3B2:(14R)-14-HYDROXY-15,15-DIMETHYL-1-[5-({[(5-METHYL-1,2-OXAZOL-3-YL)METHYL]SULFANYL}METHYL)-1,2-OXAZOL-3-YL]-4,9,13-TRIOXO-2-THIA-5,8,12-TRIAZAHEXADECAN-16-YL+DIHYDROGEN+PHOSPHATE'>3B2</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hrr|3hrr]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Noranthrone_synthase Noranthrone synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.221 2.3.1.221] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kbz OCA], [http://pdbe.org/5kbz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kbz RCSB], [http://www.ebi.ac.uk/pdbsum/5kbz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kbz ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PKSL1_ASPPA PKSL1_ASPPA]] Combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor norsolorinic acid anthrone (noranthrone) in the aflatoxin biosynthesis pathway. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase.<ref>PMID:15006741</ref> <ref>PMID:18403714</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Noranthrone synthase]] | |||
[[Category: Barajas, J F]] | |||
[[Category: Burkart, M D]] | |||
[[Category: Clair, J J.La]] | |||
[[Category: Jackson, D R]] | |||
[[Category: Moreno, G]] | |||
[[Category: Rivera, H]] | |||
[[Category: Shakya, G]] | |||
[[Category: Topper, C L]] | |||
[[Category: Townsend, C A]] | |||
[[Category: Tsai, S C]] | |||
[[Category: Vagstad, A]] | |||
[[Category: Aflatoxin]] | |||
[[Category: Cyclase]] | |||
[[Category: Dehydratase]] | |||
[[Category: Double hot dog fold]] | |||
[[Category: Polyketide]] | |||
[[Category: Polyketide synthase]] | |||
[[Category: Product template]] | |||
[[Category: Transcription]] | |||
Revision as of 12:57, 10 May 2017
Structure of the PksA Product Template domain in complex with a phosphopantetheine mimetic
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