5lxh: Difference between revisions
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==GABARAP-L1 ATG4B LIR Complex== | |||
<StructureSection load='5lxh' size='340' side='right' caption='[[5lxh]], [[Resolution|resolution]] 1.58Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5lxh]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LXH FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxh OCA], [http://pdbe.org/5lxh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lxh RCSB], [http://www.ebi.ac.uk/pdbsum/5lxh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxh ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GBRL1_HUMAN GBRL1_HUMAN]] Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles.<ref>PMID:16431922</ref> <ref>PMID:20404487</ref> [[http://www.uniprot.org/uniprot/ATG4B_HUMAN ATG4B_HUMAN]] Cysteine protease required for autophagy, which cleaves the C-terminal part of MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Also mediates the lipid deconjugation required for target recycling.<ref>PMID:15169837</ref> <ref>PMID:19322194</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Johansen, T]] | |||
[[Category: Lamark, T]] | [[Category: Lamark, T]] | ||
[[Category: | [[Category: Larsen, K Bowitz]] | ||
[[Category: Lee, R]] | |||
[[Category: | |||
[[Category: Mouilleron, S]] | [[Category: Mouilleron, S]] | ||
[[Category: | [[Category: Princely, Y Abudu]] | ||
[[Category: | [[Category: Rasmussen, M Skytte]] | ||
[[Category: | [[Category: Shrestha, B Kumar]] | ||
[[Category: Sjottem, E]] | [[Category: Sjottem, E]] | ||
[[Category: Tooze, S]] | [[Category: Tooze, S]] | ||
[[Category: Wirth, M]] | |||
[[Category: Atg8]] | |||
[[Category: Gabarap]] | |||
[[Category: Lc3]] | |||
[[Category: Lir]] | |||
[[Category: Signaling protein]] | |||
