5gug: Difference between revisions
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==Crystal structure of inositol 1,4,5-trisphosphate receptor large cytosolic domain with inositol 1,4,5-trisphosphate== | |||
<StructureSection load='5gug' size='340' side='right' caption='[[5gug]], [[Resolution|resolution]] 7.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5gug]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GUG FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gug OCA], [http://pdbe.org/5gug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gug RCSB], [http://www.ebi.ac.uk/pdbsum/5gug PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gug ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE]] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hamada, K]] | |||
[[Category: Mikoshiba, K]] | |||
[[Category: Miyatake, H]] | |||
[[Category: Terauchi, A]] | |||
[[Category: Metal transport]] | |||
[[Category: Receptor channel calcium]] | |||
Revision as of 13:56, 27 April 2017
Crystal structure of inositol 1,4,5-trisphosphate receptor large cytosolic domain with inositol 1,4,5-trisphosphate
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