5lxo: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry 5lxo~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Coiled-coil protein==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5lxo]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXO OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LXO FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxo OCA], [http://pdbe.org/5lxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lxo RCSB], [http://www.ebi.ac.uk/pdbsum/5lxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxo ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/TACC3_HUMAN TACC3_HUMAN]] Gliosarcoma;Giant cell glioblastoma.

== Function ==

[[http://www.uniprot.org/uniprot/TACC3_HUMAN TACC3_HUMAN]] Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).[UniProtKB:Q9JJ11]<ref>PMID:14767476</ref> <ref>PMID:21297582</ref> <ref>PMID:23532825</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bunney, T D]]

[[Category: Katan, M]]

[[Category: Thiyagarajan, N]]

[[Category: Cancer]]

[[Category: Coiled-coil]]

[[Category: Fgfr]]

[[Category: Fgfr fusion]]

[[Category: Fusion]]

[[Category: Growth factor]]

[[Category: Helix]]

[[Category: Parallel helix]]

[[Category: Structural protein]]

[[Category: Tacc3]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5lxo is ON HOLD  until Paper Publication
+==Coiled-coil protein==
+<StructureSection load='5lxo' size='340' side='right' caption='[[5lxo]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5lxo]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LXO FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxo OCA], [http://pdbe.org/5lxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lxo RCSB], [http://www.ebi.ac.uk/pdbsum/5lxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxo ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/TACC3_HUMAN TACC3_HUMAN]] Gliosarcoma;Giant cell glioblastoma.
+== Function ==
+[[http://www.uniprot.org/uniprot/TACC3_HUMAN TACC3_HUMAN]] Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).[UniProtKB:Q9JJ11]<ref>PMID:14767476</ref> <ref>PMID:21297582</ref> <ref>PMID:23532825</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bunney, T D]]
+[[Category: Katan, M]]
+[[Category: Thiyagarajan, N]]
+[[Category: Cancer]]
+[[Category: Coiled-coil]]
+[[Category: Fgfr]]
+[[Category: Fgfr fusion]]
+[[Category: Fusion]]
+[[Category: Growth factor]]
+[[Category: Helix]]
+[[Category: Parallel helix]]
+[[Category: Structural protein]]
+[[Category: Tacc3]]