5lyo: Difference between revisions
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==Crystal structure of the zymogen matriptase catalytic domain== | |||
<StructureSection load='5lyo' size='340' side='right' caption='[[5lyo]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5lyo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LYO FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Matriptase Matriptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.109 3.4.21.109] </span></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lyo OCA], [http://pdbe.org/5lyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lyo RCSB], [http://www.ebi.ac.uk/pdbsum/5lyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lyo ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Matriptase]] | |||
[[Category: Hong, Z]] | [[Category: Hong, Z]] | ||
[[Category: Jensen, J K]] | |||
[[Category: Enzyme inhibitor]] | |||
[[Category: Hydrolase-inhibitor complex]] | |||
[[Category: Serine protease]] | |||
[[Category: Zymogen]] | |||
Revision as of 07:12, 25 October 2017
Crystal structure of the zymogen matriptase catalytic domain
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