5tcx: Difference between revisions
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The | ==Crystal structure of human tetraspanin CD81== | ||
<StructureSection load='5tcx' size='340' side='right' caption='[[5tcx]], [[Resolution|resolution]] 2.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5tcx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TCX FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tcx OCA], [http://pdbe.org/5tcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tcx RCSB], [http://www.ebi.ac.uk/pdbsum/5tcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tcx ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[http://omim.org/entry/613496 613496]]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Blacklow, S C]] | |||
[[Category: Kruse, A C]] | |||
[[Category: McMillan, B J]] | |||
[[Category: Seegar, T C.M]] | |||
[[Category: Zimmerman, B]] | |||
[[Category: Cell invasion]] | |||
[[Category: Cholesterol]] | |||
[[Category: Tetraspanin]] | |||
[[Category: Transmembrane]] | |||
Revision as of 19:59, 9 December 2016
Crystal structure of human tetraspanin CD81
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