5k6s: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry~~ 5k6s is ~~ON HOLD~~ ~~until Paper Publication~~

==The structure of the PP2A B56 subunit BubR1 complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5k6s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K6S FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k6s OCA], [http://pdbe.org/5k6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k6s RCSB], [http://www.ebi.ac.uk/pdbsum/5k6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k6s ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/2A5G_HUMAN 2A5G_HUMAN]] The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.<ref>PMID:16456541</ref> <ref>PMID:17245430</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bajaj, R]]

[[Category: Page, R]]

[[Category: Peti, W]]

[[Category: Wang, X]]

[[Category: Cell cycle]]

[[Category: Hydrolase]]

[[Category: Phosphatase]]

[[Category: Regulator]]

[[Category: Slim]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5k6s is ON HOLD  until Paper Publication
+==The structure of the PP2A B56 subunit BubR1 complex==
+<StructureSection load='5k6s' size='340' side='right' caption='[[5k6s]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5k6s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K6S FirstGlance]. <br>
-Description:
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k6s OCA], [http://pdbe.org/5k6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k6s RCSB], [http://www.ebi.ac.uk/pdbsum/5k6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k6s ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/2A5G_HUMAN 2A5G_HUMAN]] The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.<ref>PMID:16456541</ref> <ref>PMID:17245430</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bajaj, R]]
+[[Category: Page, R]]
+[[Category: Peti, W]]
+[[Category: Wang, X]]
+[[Category: Cell cycle]]
+[[Category: Hydrolase]]
+[[Category: Phosphatase]]
+[[Category: Regulator]]
+[[Category: Slim]]