5th7: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5th7 is ON HOLD
==Complex of SETD8 with MS453==
 
<StructureSection load='5th7' size='340' side='right' caption='[[5th7]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
Authors: Yu, W., Tempel, W., Babault, N., Ma, A., Butler, K.V., Jin, J., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5th7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TH7 FirstGlance]. <br>
Description: Complex of SETD8 with MS453
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7BY:N-(3-{[6,7-DIMETHOXY-2-(PYRROLIDIN-1-YL)QUINAZOLIN-4-YL]AMINO}PROPYL)PROPANAMIDE'>7BY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5th7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5th7 OCA], [http://pdbe.org/5th7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5th7 RCSB], [http://www.ebi.ac.uk/pdbsum/5th7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5th7 ProSAT]</span></td></tr>
[[Category: Yu, W]]
</table>
[[Category: Butler, K.V]]
== Function ==
[[http://www.uniprot.org/uniprot/KMT5A_HUMAN KMT5A_HUMAN]] Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.<ref>PMID:12086618</ref> <ref>PMID:12121615</ref> <ref>PMID:15200950</ref> <ref>PMID:15933069</ref> <ref>PMID:15933070</ref> <ref>PMID:16517599</ref> <ref>PMID:17707234</ref> <ref>PMID:23478445</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Babault, N]]
[[Category: Babault, N]]
[[Category: Bountra, C]]
[[Category: Brown, P J]]
[[Category: Butler, K V]]
[[Category: Edwards, A M]]
[[Category: Jin, J]]
[[Category: Jin, J]]
[[Category: Bountra, C]]
[[Category: Ma, A]]
[[Category: Structural genomic]]
[[Category: Tempel, W]]
[[Category: Tempel, W]]
[[Category: Arrowsmith, C.H]]
[[Category: Yu, W]]
[[Category: Brown, P.J]]
[[Category: Sgc]]
[[Category: Edwards, A.M]]
[[Category: Transferase]]
[[Category: Ma, A]]
[[Category: Structural Genomics Consortium (Sgc)]]
Retrieved from "https://proteopedia.org/5th7"