5ti9: Difference between revisions
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==Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural Genomics Consortium Target HR6161== | |||
<StructureSection load='5ti9' size='340' side='right' caption='[[5ti9]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ti9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TI9 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NFK:N-FORMYLKYNURENINE'>NFK</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tia|5tia]]</td></tr> | ||
[[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ti9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ti9 OCA], [http://pdbe.org/5ti9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ti9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ti9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ti9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN]] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Tryptophan 2,3-dioxygenase]] | |||
[[Category: Forouhar, F]] | [[Category: Forouhar, F]] | ||
[[Category: Structural genomic]] | |||
[[Category: Tong, L]] | [[Category: Tong, L]] | ||
[[Category: 3-dioxygenase in complex with trp and o2]] | |||
[[Category: Human tryptophan 2]] | |||
[[Category: Nesg]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: PSI, Protein structure initiative]] | |||
[[Category: Psi-biology]] | |||
