5tkb: Difference between revisions

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'''Unreleased structure'''


The entry 5tkb is ON HOLD  until Paper Publication
==CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND==
 
<StructureSection load='5tkb' size='340' side='right' caption='[[5tkb]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
Authors: Sack, J.S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5tkb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TKB FirstGlance]. <br>
Description: CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7DJ:N-[(2R)-2,3-DIHYDROXY-2-METHYLPROPYL]-8-(METHYLAMINO)-6-[(2,3,5,6-TETRAFLUOROPHENYL)AMINO]IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXAMIDE'>7DJ</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>
[[Category: Sack, J.S]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tkb OCA], [http://pdbe.org/5tkb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tkb RCSB], [http://www.ebi.ac.uk/pdbsum/5tkb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tkb ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution.  Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[http://omim.org/entry/614613 614613]]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: 3',5'-cyclic-AMP phosphodiesterase]]
[[Category: Sack, J S]]
[[Category: Alternative splicing]]
[[Category: Camp]]
[[Category: Cytoplasm]]
[[Category: Cytoskeleton]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Membrane]]
[[Category: Metal- binding]]
[[Category: Pde4d]]
[[Category: Phosphodiesterase]]
[[Category: Phosphoprotein]]
Retrieved from "https://proteopedia.org/5tkb"