Sandbox 9888: Difference between revisions

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Beginning human trials, Vilcek and his team caught the attention of several drug companies, especially Centocor. Their hope was to have discovered a means of treating cancer using the body’s own immune system. Rather, the extraordinary protein they had discovered in 1993 was highly toxic, even at low doses. Although, the study did not result in the desired outcome, the team further researched the use of TNF for other clinical applications.

Using the knowledge of TNF-α as a pro-inflammatory cytokine, Vilcek started exploring the generation of antibodies for the protein. Murine mice were used as a model organism to develop the first monoclonal antibody, A2. This antibody was found to bind to TNF-thus causing the reduction of inflammation in systemic immune responses. The use of TNF inhibitors to treat diseases that were known to induce excessive inflammation, would be the foundation of Remicade. This was an engineered chimeric antibody, created by the combination of mouse and human TNF that allowed for a higher specificity and affinity to the TNF receptor. With the collaborative efforts of Centocor, Remicade became the first receptor specific antibody for TNF-α on the market.

Using the knowledge of TNF-α as a pro-inflammatory cytokine, Vilcek started exploring the generation of antibodies for the protein. Murine mice were used as a model organism to develop the first monoclonal antibody, A2. This antibody was found to bind to TNF-thus causing the reduction of inflammation in systemic immune responses. The use of TNF inhibitors to treat diseases that were known to induce excessive inflammation, would be the foundation of Remicade. This was an engineered chimeric antibody, created by the combination of mouse and human TNF that allowed for a higher specificity and affinity to the TNF receptor. With the collaborative efforts of Centocor, Remicade became the first receptor specific antibody for TNF-α on the market <ref name="businessIn">Ramsey, L. (2015). One of the world’s blockbuster drugs might not exist if its research hadn't flopped in a major way. Retrieved from http://www.businessinsider.com/remicade-would-have-failed-as-a-cancer-drug-2015-12</ref>.

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Sandbox 9888: Difference between revisions

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 Beginning human trials, Vilcek and his team caught the attention of several drug companies, especially Centocor. Their hope was to have discovered a means of treating cancer using the body’s own immune system. Rather, the extraordinary protein they had discovered in 1993 was highly toxic, even at low doses. Although, the study did not result in the desired outcome, the team further researched the use of TNF for other clinical applications.
-Using the knowledge of TNF-α as a pro-inflammatory cytokine, Vilcek started exploring the generation of antibodies for the protein. Murine mice were used as a model organism to develop the first monoclonal antibody, A2. This antibody was found to bind to TNF-thus causing the reduction of inflammation in systemic immune responses. The use of TNF inhibitors to treat diseases that were known to induce excessive inflammation, would be the foundation of Remicade. This was an engineered chimeric antibody, created by the combination of mouse and human TNF that allowed for a higher specificity and affinity to the TNF receptor. With the collaborative efforts of Centocor, Remicade became the first receptor specific antibody for TNF-α on the market.
+Using the knowledge of TNF-α as a pro-inflammatory cytokine, Vilcek started exploring the generation of antibodies for the protein. Murine mice were used as a model organism to develop the first monoclonal antibody, A2. This antibody was found to bind to TNF-thus causing the reduction of inflammation in systemic immune responses. The use of TNF inhibitors to treat diseases that were known to induce excessive inflammation, would be the foundation of Remicade. This was an engineered chimeric antibody, created by the combination of mouse and human TNF that allowed for a higher specificity and affinity to the TNF receptor. With the collaborative efforts of Centocor, Remicade became the first receptor specific antibody for TNF-α on the market <ref name="businessIn">Ramsey, L. (2015). One of the world’s blockbuster drugs might not exist if its research hadn't flopped in a major way. Retrieved from http://www.businessinsider.com/remicade-would-have-failed-as-a-cancer-drug-2015-12</ref>.
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