5ewv: Difference between revisions
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==Crystal structure of the human BRPF1 bromodomain in complex with SEED20== | |||
<StructureSection load='5ewv' size='340' side='right' caption='[[5ewv]], [[Resolution|resolution]] 1.67Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ewv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EWV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5SN:1,5-DIMETHYL-[1,2,4]TRIAZOLO[4,3-A]QUINOLINE'>5SN</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5c7n|5c7n]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ewv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ewv OCA], [http://pdbe.org/5ewv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ewv RCSB], [http://www.ebi.ac.uk/pdbsum/5ewv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ewv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caflisch, A]] | [[Category: Caflisch, A]] | ||
[[Category: Wiedmer, L]] | [[Category: Wiedmer, L]] | ||
[[Category: Zhu, J]] | [[Category: Zhu, J]] | ||
[[Category: Dna binding protein]] | |||
[[Category: Inhibitor]] | |||
[[Category: Transcription]] | |||
Revision as of 18:26, 2 November 2016
Crystal structure of the human BRPF1 bromodomain in complex with SEED20
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