5tcf: Difference between revisions

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'''Unreleased structure'''


The entry 5tcf is ON HOLD  until Paper Publication
==Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form==
 
<StructureSection load='5tcf' size='340' side='right' caption='[[5tcf]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
Authors: Michalska, K., Maltseva, N.I., Jedrzejczak, R., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5tcf]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TCF FirstGlance]. <br>
Description: Crystal structure of tryptophan synthase from M. tuberculosis -ligand-free form
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tcg|5tcg]], [[5tch|5tch]], [[5tci|5tci]], [[5tcj|5tcj]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tcf OCA], [http://pdbe.org/5tcf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tcf RCSB], [http://www.ebi.ac.uk/pdbsum/5tcf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tcf ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TRPA_MYCTU TRPA_MYCTU]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_MYCTU TRPB_MYCTU]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine (By similarity).
__TOC__
</StructureSection>
[[Category: Tryptophan synthase]]
[[Category: Structural genomic]]
[[Category: Jedrzejczak, R]]
[[Category: Joachimiak, A]]
[[Category: Maltseva, N]]
[[Category: Michalska, K]]
[[Category: Michalska, K]]
[[Category: Joachimiak, A]]
[[Category: Allostery]]
[[Category: Maltseva, N.I]]
[[Category: Amino acid biosynthesis]]
[[Category: Jedrzejczak, R]]
[[Category: Csgid]]
[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
[[Category: Heterotetramer]]
[[Category: Lyase]]
[[Category: Plp]]
[[Category: Substrate channeling]]
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