5m5g: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5m5g is ~~ON HOLD~~

==Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2)==

== Structural highlights ==

<table><tr><td colspan='2'>[[5m5g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M5G FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ch1|5ch1]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m5g OCA], [http://pdbe.org/5m5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m5g RCSB], [http://www.ebi.ac.uk/pdbsum/5m5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m5g ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.

~~Authors~~:

Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".,Zhang Y, Justin N, Wilson JR, Gamblin SJ Science. 2016 Dec 23;354(6319):1543. doi: 10.1126/science.aaf6236. PMID:28008037<ref>PMID:28008037</ref>

~~Description~~:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

[[Category: ~~Unreleased Structures~~]]

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Gamblin, S]]

[[Category: Justin, N]]

[[Category: Wilson, J]]

[[Category: Zhang, Y]]

[[Category: Complex]]

[[Category: Repressive]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5m5g is ON HOLD
+==Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2)==
+<StructureSection load='5m5g' size='340' side='right' caption='[[5m5g]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5m5g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M5G FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ch1|5ch1]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m5g OCA], [http://pdbe.org/5m5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m5g RCSB], [http://www.ebi.ac.uk/pdbsum/5m5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m5g ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.
-Authors:
+Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".,Zhang Y, Justin N, Wilson JR, Gamblin SJ Science. 2016 Dec 23;354(6319):1543. doi: 10.1126/science.aaf6236. PMID:28008037<ref>PMID:28008037</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 5m5g" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gamblin, S]]
+[[Category: Justin, N]]
+[[Category: Wilson, J]]
+[[Category: Zhang, Y]]
+[[Category: Complex]]
+[[Category: Repressive]]
+[[Category: Transferase]]