5m72: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5m72 is ~~ON HOLD until Paper Publication~~

==Structure of the human SRP68-72 protein-binding domain complex==

~~Authors~~: ~~Becker~~, M.M.M., ~~Wild~~, K., ~~Sinning~~, I.

== Structural highlights ==

<table><tr><td colspan='2'>[[5m72]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M72 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M72 FirstGlance]. <br>

~~Description~~: ~~Structure~~ of the ~~human SRP68~~-~~72 protein~~-~~binding domain~~ complex

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m72 OCA], [http://pdbe.org/5m72 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m72 RCSB], [http://www.ebi.ac.uk/pdbsum/5m72 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m72 ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/SRP72_HUMAN SRP72_HUMAN]] Autosomal dominant aplasia and myelodysplasia. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/SRP72_HUMAN SRP72_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. [[http://www.uniprot.org/uniprot/SRP68_HUMAN SRP68_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

__TOC__

</StructureSection>

[[Category: Becker, M M.M]]

[[Category: Sinning, I]]

[[Category: Wild, K]]

[[Category: ~~Becker, M.M.M~~]]

[[Category: Protein targeting]]

[[Category: ~~Sinning, I~~]]

[[Category: Protein transport]]

[[Category: Protein-peptide complex]]

[[Category: Signal recognition particle]]

[[Category: Tetratricopeptide repeat]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5m72 is ON HOLD  until Paper Publication
+==Structure of the human SRP68-72 protein-binding domain complex==
+<StructureSection load='5m72' size='340' side='right' caption='[[5m72]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-Authors: Becker, M.M.M., Wild, K., Sinning, I.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5m72]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M72 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M72 FirstGlance]. <br>
-Description: Structure of the human SRP68-72 protein-binding domain complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m72 OCA], [http://pdbe.org/5m72 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m72 RCSB], [http://www.ebi.ac.uk/pdbsum/5m72 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m72 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/SRP72_HUMAN SRP72_HUMAN]] Autosomal dominant aplasia and myelodysplasia. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/SRP72_HUMAN SRP72_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. [[http://www.uniprot.org/uniprot/SRP68_HUMAN SRP68_HUMAN]] Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
+__TOC__
+</StructureSection>
+[[Category: Becker, M M.M]]
+[[Category: Sinning, I]]
 [[Category: Wild, K]]
-[[Category: Becker, M.M.M]]
+[[Category: Protein targeting]]
-[[Category: Sinning, I]]
+[[Category: Protein transport]]
+[[Category: Protein-peptide complex]]
+[[Category: Signal recognition particle]]
+[[Category: Tetratricopeptide repeat]]