5tpt: Difference between revisions
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The | ==The Crystal Structure of Amyloid Precursor-Like Protein 2 (APLP2) E2 Domain== | ||
<StructureSection load='5tpt' size='340' side='right' caption='[[5tpt]], [[Resolution|resolution]] 2.42Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5tpt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TPT FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tpt OCA], [http://pdbe.org/5tpt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tpt RCSB], [http://www.ebi.ac.uk/pdbsum/5tpt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tpt ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/APLP2_HUMAN APLP2_HUMAN]] May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).<ref>PMID:8307156</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cappai, R]] | |||
[[Category: Roisman, L C]] | |||
[[Category: Alzheimer's disease]] | |||
[[Category: Amyloid precursor protein family]] | |||
[[Category: Protein fibril]] | |||
Revision as of 05:48, 6 June 2018
The Crystal Structure of Amyloid Precursor-Like Protein 2 (APLP2) E2 Domain
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