Prinivil/Sandbox 1: Difference between revisions

Revision as of 21:59, 16 November 2016 view source Robert Sherman (talk \| contribs) 74 edits No edit summary ← Older edit		Revision as of 21:59, 16 November 2016 view source Robert Sherman (talk \| contribs) 74 edits No edit summary Newer edit →
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	ACE Active site has a NH3+ group which binds to the COOH terminus of the drug. NH of the enzyme binds to the middle C=O group of the drug. The benzene ring of the drug fits into a hydrophobic pocket(S1) of the enzyme. The 5-membered nitrogenous ring of the drug fits to the S2’ pocket. The lysine segment fits into the S1’ pocket.		ACE Active site has a NH3+ group which binds to the COOH terminus of the drug. NH of the enzyme binds to the middle C=O group of the drug. The benzene ring of the drug fits into a hydrophobic pocket(S1) of the enzyme. The 5-membered nitrogenous ring of the drug fits to the S2’ pocket. The lysine segment fits into the S1’ pocket.

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