Invanz Sandbox: Difference between revisions

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Invanz (Ertapenem) is a 1-beta-methyl carbapenem antibiotic that is designed to treat multi drug resistant bacterial infections such as intra-abdominal infections, skin and skin suture infections, community-acquired pneumonia, complicated urinary tract infections including pyelonephritis, acute pelvic infections, and can be used as a prophylactic measure prior to colorectal surgery. Invanz is an injectable antibiotic ~~that~~ can be administered intramuscularly~~, and~~ is generally known to be an antibiotic to treat mostly life-threatening infections and is used sparingly <ref>Merck, Sharp, and Dohme Corporation. Highlight of Prescribing Information: Invanz. http://www.merck.com/product/usa/pi_circulars/i/invanz/invanz_pi.pdf (accessed November, 12 2016)</ref><ref name="merck">...</ref>.

Invanz (Ertapenem) is a 1-beta-methyl carbapenem antibiotic that is designed to treat multi drug resistant bacterial infections such as intra-abdominal infections, skin and skin suture infections, community-acquired pneumonia, complicated urinary tract infections including pyelonephritis, acute pelvic infections, and can be used as a prophylactic measure prior to colorectal surgery. Invanz is an injectable antibiotic, which can be administered intramuscularly. It is generally known to be an antibiotic to treat mostly life-threatening infections and is used sparingly <ref>Merck, Sharp, and Dohme Corporation. Highlight of Prescribing Information: Invanz. http://www.merck.com/product/usa/pi_circulars/i/invanz/invanz_pi.pdf (accessed November, 12 2016)</ref><ref name="merck">...</ref>.

== Function ==

Invanz is used to treat a range of bacterial infections caused by Gram positive ~~and~~ Gram negative bacteria as well as a range of both aerobic and anaerobic bacteria. Invanz works by inhibiting cell wall synthesis via binding to penicillin binding proteins (PBPs). Invanz is stable against hydrolysis from many beta-lactamases including penicillinases and cephalosporinases, but is unstable against metallo-beta-lactamases <ref name="merck" />. Beta-lactamases are secreted by bacteria to provide resistance to antibiotics; however, Invanz is relatively unaffected by these beta-lactamases and thus is an effective treatment for various bacterial infections <ref>PMID: 25561890</ref>. The unique structural features of Invanz equip this drug with some of the widest spectrum and most potent antimicrobial activity of carbapenem antibiotics today <ref>PMID: 12951340</ref>.

Invanz is used to treat a range of bacterial infections caused by Gram positive bacteria, Gram negative bacteria, and as well as a range of both aerobic and anaerobic bacteria. Invanz works by inhibiting cell wall synthesis via binding to penicillin binding proteins (PBPs). Invanz is stable against hydrolysis from many beta-lactamases including penicillinases and cephalosporinases, but is unstable against metallo-beta-lactamases <ref name="merck" />. Beta-lactamases are secreted by bacteria to provide resistance to antibiotics; however, Invanz is relatively unaffected by these beta-lactamases and thus is an effective treatment for various bacterial infections <ref>PMID: 25561890</ref>. The unique structural features of Invanz equip this drug with some of the widest spectrum and most potent antimicrobial activity of carbapenem antibiotics today <ref>PMID: 12951340</ref>.

== Structural highlights ==

Invanz Sandbox: Difference between revisions

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-Invanz (Ertapenem) is a 1-beta-methyl carbapenem antibiotic that is designed to treat multi drug resistant bacterial infections such as intra-abdominal infections, skin and skin suture infections, community-acquired pneumonia, complicated urinary tract infections including pyelonephritis, acute pelvic infections, and can be used as a prophylactic measure prior to colorectal surgery. Invanz is an injectable antibiotic that can be administered intramuscularly, and is generally known to be an antibiotic to treat mostly life-threatening infections and is used sparingly <ref>Merck, Sharp, and Dohme Corporation. Highlight of Prescribing Information: Invanz. http://www.merck.com/product/usa/pi_circulars/i/invanz/invanz_pi.pdf (accessed November, 12 2016)</ref><ref name="merck">...</ref>.
+Invanz (Ertapenem) is a 1-beta-methyl carbapenem antibiotic that is designed to treat multi drug resistant bacterial infections such as intra-abdominal infections, skin and skin suture infections, community-acquired pneumonia, complicated urinary tract infections including pyelonephritis, acute pelvic infections, and can be used as a prophylactic measure prior to colorectal surgery. Invanz is an injectable antibiotic, which can be administered intramuscularly. It is generally known to be an antibiotic to treat mostly life-threatening infections and is used sparingly <ref>Merck, Sharp, and Dohme Corporation. Highlight of Prescribing Information: Invanz. http://www.merck.com/product/usa/pi_circulars/i/invanz/invanz_pi.pdf (accessed November, 12 2016)</ref><ref name="merck">...</ref>.
 <Structure load='InvanzStick.pdb' size='350' frame='true' align='right' caption='Structure of Invanz and its crystallized complexes that characterize its effective action against a variety of difficult to treat bacteria' scene='' />
 == Function ==
-Invanz is used to treat a range of bacterial infections caused by Gram positive and Gram negative bacteria as well as a range of both aerobic and anaerobic bacteria. Invanz works by inhibiting cell wall synthesis via binding to penicillin binding proteins (PBPs). Invanz is stable against hydrolysis from many beta-lactamases including penicillinases and cephalosporinases, but is unstable against metallo-beta-lactamases <ref name="merck" />. Beta-lactamases are secreted by bacteria to provide resistance to antibiotics; however, Invanz is relatively unaffected by these beta-lactamases and thus is an effective treatment for various bacterial infections <ref>PMID: 25561890</ref>. The unique structural features of Invanz equip this drug with some of the widest spectrum and most potent antimicrobial activity of carbapenem antibiotics today <ref>PMID: 12951340</ref>.
+Invanz is used to treat a range of bacterial infections caused by Gram positive bacteria, Gram negative bacteria, and as well as a range of both aerobic and anaerobic bacteria. Invanz works by inhibiting cell wall synthesis via binding to penicillin binding proteins (PBPs). Invanz is stable against hydrolysis from many beta-lactamases including penicillinases and cephalosporinases, but is unstable against metallo-beta-lactamases <ref name="merck" />. Beta-lactamases are secreted by bacteria to provide resistance to antibiotics; however, Invanz is relatively unaffected by these beta-lactamases and thus is an effective treatment for various bacterial infections <ref>PMID: 25561890</ref>. The unique structural features of Invanz equip this drug with some of the widest spectrum and most potent antimicrobial activity of carbapenem antibiotics today <ref>PMID: 12951340</ref>.
 == Structural highlights ==