Ribavirin: Difference between revisions

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== Structure & Function ==

While the main function of Ribavirin is to treat Hepatitis C and RSV, Ribavirin alone is not enough to treat these diseases and is commonly combined with interferon alpha2b<ref name="gish"/> . Ribavirin contains antiviral activity which inhibits DNA/RNA synthesis. It is chemically classified as a nucleoside analogy because the structure of Ribavirin resembles the structure of the nucleoside guanosine. <ref>https://pubchem.ncbi.nlm.nih.gov/compound/37542<ref> Like guanosine, ribavirin is also water soluble and is able to mimic other purines (other than guanosine) as well. However, a key difference between the structure of ribavirin and the purine nucleosides is that the heterocyclic base contains only one ring, as opposed to purines which have two. Despite this, it is able to go through similar mechanisms as that of nucleosides such as phosphorylating into a triphosphate. Its structural similarity to the common nucleoside guanosine may suggest how the drug can inhibit DNA/RNA synthesis through purine mimicry. <ref name="structure"> doi: 10.3851/IMP2125 </ref~~> <scene name='74/746008/Ribavirin_atalla2/1'>Ribavirin</scene> [[4pb1]]~~

While the main function of Ribavirin is to treat Hepatitis C and RSV, Ribavirin alone is not enough to treat these diseases and is commonly combined with interferon alpha2b<ref name="gish"/> . Ribavirin contains antiviral activity which inhibits DNA/RNA synthesis. It is chemically classified as a nucleoside analogy because the structure of Ribavirin resembles the structure of the nucleoside guanosine. <ref>https://pubchem.ncbi.nlm.nih.gov/compound/37542<ref> Like guanosine, ribavirin is also water soluble and is able to mimic other purines (other than guanosine) as well. However, a key difference between the structure of ribavirin and the purine nucleosides is that the heterocyclic base contains only one ring, as opposed to purines which have two. Despite this, it is able to go through similar mechanisms as that of nucleosides such as phosphorylating into a triphosphate. Its structural similarity to the common nucleoside guanosine may suggest how the drug can inhibit DNA/RNA synthesis through purine mimicry. <ref name="structure"> doi: 10.3851/IMP2125 </ref>

~~[[Image:Ribavirin Structure1.gif]]~~

~~Comparison of the 2D structure of ribavirin to the structures of the nuceoside guanosine and a simliar anti-viral drug viramidine. <ref name= "structure"/~~>

Ribavirin: Difference between revisions

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 == Structure & Function ==
-While the main function of Ribavirin is to treat Hepatitis C and RSV, Ribavirin alone is not enough to treat these diseases and is commonly combined with interferon alpha2b<ref name="gish"/> . Ribavirin contains antiviral activity which inhibits DNA/RNA synthesis. It is chemically classified as a nucleoside analogy because the structure of Ribavirin resembles the structure of the nucleoside guanosine. <ref>https://pubchem.ncbi.nlm.nih.gov/compound/37542<ref> Like guanosine, ribavirin is also water soluble and is able to mimic other purines (other than guanosine) as well. However, a key difference between the structure of ribavirin and the purine nucleosides is that the heterocyclic base contains only one ring, as opposed to purines which have two. Despite this, it is able to go through similar mechanisms as that of nucleosides such as phosphorylating into a triphosphate. Its structural similarity to the common nucleoside guanosine may suggest how the drug can inhibit DNA/RNA synthesis through purine mimicry. <ref name="structure"> doi: 10.3851/IMP2125 </ref> <scene name='74/746008/Ribavirin_atalla2/1'>Ribavirin</scene> [[4pb1]]
+While the main function of Ribavirin is to treat Hepatitis C and RSV, Ribavirin alone is not enough to treat these diseases and is commonly combined with interferon alpha2b<ref name="gish"/> . Ribavirin contains antiviral activity which inhibits DNA/RNA synthesis. It is chemically classified as a nucleoside analogy because the structure of Ribavirin resembles the structure of the nucleoside guanosine. <ref>https://pubchem.ncbi.nlm.nih.gov/compound/37542<ref> Like guanosine, ribavirin is also water soluble and is able to mimic other purines (other than guanosine) as well. However, a key difference between the structure of ribavirin and the purine nucleosides is that the heterocyclic base contains only one ring, as opposed to purines which have two. Despite this, it is able to go through similar mechanisms as that of nucleosides such as phosphorylating into a triphosphate. Its structural similarity to the common nucleoside guanosine may suggest how the drug can inhibit DNA/RNA synthesis through purine mimicry. <ref name="structure"> doi: 10.3851/IMP2125 </ref>
-[[Image:Ribavirin Structure1.gif]]
-Comparison of the 2D structure of ribavirin to the structures of the nuceoside guanosine and a simliar anti-viral drug viramidine. <ref name= "structure"/>