5g20: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5g20 ~~is ON HOLD until Paper Publication~~

==Leishmania major N-myristoyltransferase in complex with a quinoline inhibitor (compound 19).==

~~Authors~~: ~~Goncalves, V~~.~~, Brannigan, J~~.A., ~~Laporte~~, A., ~~Bell~~, A.S., ~~Roberts~~, S.M., ~~Wilkinson~~, A.J., ~~Leatherbarrow, R~~.J., ~~Tate, E~~.W.

== Structural highlights ==

<table><tr><td colspan='2'>[[5g20]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G20 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G20 FirstGlance].

~~Description~~: ~~Leishmania major~~ N-~~myristoyltransferase in complex with a quinoline inhibitor~~ (~~compound 19~~).

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=QBY:6-(BENZYLOXY)-4-(ETHYLSULFANYL)-3-[(MORPHOLIN-4-YL)'>QBY</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5g1z|5g1z]], [[5g21|5g21]], [[5g22|5g22]]</td></tr>

[[Category: ~~Wilkinson~~, A~~.J]]~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </td></tr>

~~[[Category: Leatherbarrow, R.J~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g20 OCA], [http://pdbe.org/5g20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g20 RCSB], [http://www.ebi.ac.uk/pdbsum/5g20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g20 ProSAT]</td></tr>

[[Category: Brannigan, J.A]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).

__TOC__

</StructureSection>

[[Category: Glycylpeptide N-tetradecanoyltransferase]]

[[Category: Bell, A S]]

[[Category: Brannigan, J A]]

[[Category: Goncalves, V]]

~~[[Category: Roberts, S.M]]~~

~~[[Category: Tate, E.W]]~~

[[Category: Laporte, A]]

[[Category: ~~Bell~~, A.S]]

[[Category: Leatherbarrow, R J]]

[[Category: Roberts, S M]]

[[Category: Tate, E W]]

[[Category: Wilkinson, A J]]

[[Category: Drug design]]

[[Category: Inhibitor]]

[[Category: Malaria]]

[[Category: Myristoylation]]

[[Category: Quinoline]]

[[Category: Transferase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5g20 is ON HOLD  until Paper Publication
+==Leishmania major N-myristoyltransferase in complex with a quinoline inhibitor (compound 19).==
+<StructureSection load='5g20' size='340' side='right' caption='[[5g20]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
-Authors: Goncalves, V., Brannigan, J.A., Laporte, A., Bell, A.S., Roberts, S.M., Wilkinson, A.J., Leatherbarrow, R.J., Tate, E.W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5g20]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G20 FirstGlance]. <br>
-Description: Leishmania major N-myristoyltransferase in complex with a quinoline inhibitor (compound 19).
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=QBY:6-(BENZYLOXY)-4-(ETHYLSULFANYL)-3-[(MORPHOLIN-4-YL)'>QBY</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g1z|5g1z]], [[5g21|5g21]], [[5g22|5g22]]</td></tr>
-[[Category: Wilkinson, A.J]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-[[Category: Leatherbarrow, R.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g20 OCA], [http://pdbe.org/5g20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g20 RCSB], [http://www.ebi.ac.uk/pdbsum/5g20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g20 ProSAT]</span></td></tr>
-[[Category: Brannigan, J.A]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Glycylpeptide N-tetradecanoyltransferase]]
+[[Category: Bell, A S]]
+[[Category: Brannigan, J A]]
 [[Category: Goncalves, V]]
-[[Category: Roberts, S.M]]
-[[Category: Tate, E.W]]
 [[Category: Laporte, A]]
-[[Category: Bell, A.S]]
+[[Category: Leatherbarrow, R J]]
+[[Category: Roberts, S M]]
+[[Category: Tate, E W]]
+[[Category: Wilkinson, A J]]
+[[Category: Drug design]]
+[[Category: Inhibitor]]
+[[Category: Malaria]]
+[[Category: Myristoylation]]
+[[Category: Quinoline]]
+[[Category: Transferase]]