5kzq: Difference between revisions

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'''Unreleased structure'''


The entry 5kzq is ON HOLD until Paper Publication
==Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid==
 
<StructureSection load='5kzq' size='340' side='right' caption='[[5kzq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5kzq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KZQ FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6YS:(1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-AZANYL-3-[[3,4-BIS(FLUORANYL)PHENYL]SULFANYLMETHYL]-4-OXIDANYL-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC+ACID'>6YS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kzn|5kzn]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kzq OCA], [http://pdbe.org/5kzq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kzq RCSB], [http://www.ebi.ac.uk/pdbsum/5kzq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kzq ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Antonysamy, S]]
[[Category: Atwell, S]]
[[Category: Barberis, M]]
[[Category: Bedwell, D]]
[[Category: Blanco, M J]]
[[Category: Bradley, C]]
[[Category: Britton, T]]
[[Category: Bures, M]]
[[Category: Carpintero, M]]
[[Category: Catlow, J]]
[[Category: Chappell, M D]]
[[Category: Condon, B]]
[[Category: Conners, K]]
[[Category: Diego, J E.de]]
[[Category: Dressman, B A]]
[[Category: Erickson, J A]]
[[Category: Fivush, A M]]
[[Category: Garcia-Cerrada, S]]
[[Category: Groshong, C]]
[[Category: Heinz, B A]]
[[Category: Jaramillo, C]]
[[Category: Koss, J W]]
[[Category: Li, R]]
[[Category: Li, X]]
[[Category: MacEwan, I]]
[[Category: Matt, J]]
[[Category: Mayhugh, D]]
[[Category: Mitch, C H]]
[[Category: Monn, J A]]
[[Category: Ornstein, P]]
[[Category: Overshiner, C]]
[[Category: Quimby, S J]]
[[Category: Schkeryantz, J M]]
[[Category: Seidel, W]]
[[Category: Smith, S C]]
[[Category: Soriano, J F]]
[[Category: Swanson, S]]
[[Category: Tripp, A E]]
[[Category: Tromiczak, E G]]
[[Category: Vetman, T]]
[[Category: Wafford, K A]]
[[Category: Wang, J]]
[[Category: Wang, X S]]
[[Category: Wasserman, S R]]
[[Category: Witkin, J M]]
[[Category: Zhang, A]]
[[Category: Antagonist]]
[[Category: Antidepressent]]
[[Category: Mglur2]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/5kzq"