5mgl: Difference between revisions
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==Crystal Structure of BAZ2A bromodomain in complex with 4-chloropyridine derivative 3== | |||
<StructureSection load='5mgl' size='340' side='right' caption='[[5mgl]], [[Resolution|resolution]] 2.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5mgl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MGL FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7MU:4-CHLORANYL-~{N}-METHYL-PYRIDINE-2-CARBOXAMIDE'>7MU</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5mgg|5mgg]], [[5mgj|5mgj]], [[5mgk|5mgk]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mgl OCA], [http://pdbe.org/5mgl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mgl RCSB], [http://www.ebi.ac.uk/pdbsum/5mgl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mgl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caflisch, A]] | |||
[[Category: Lolli, G]] | [[Category: Lolli, G]] | ||
[[Category: Spiliotopoulos, D]] | [[Category: Spiliotopoulos, D]] | ||
[[Category: | [[Category: Four helical bundle]] | ||
[[Category: Transcription]] | |||
Revision as of 11:45, 12 April 2017
Crystal Structure of BAZ2A bromodomain in complex with 4-chloropyridine derivative 3
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