5ttw: Difference between revisions

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'''Unreleased structure'''


The entry 5ttw is ON HOLD
==Crystal Structure of EED in Complex with UNC4859==
 
<StructureSection load='5ttw' size='340' side='right' caption='[[5ttw]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
Authors: The, J., Barnash, K.D., Brown, P.J., Edwards, A.M., Bountra, C., Frye, S.V., James, L.I., Arrowsmith, C.H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5ttw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TTW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TTW FirstGlance]. <br>
Description: Crystal Structure of EED in Complex with UNC4859
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=NLW:L-LEUCINAMIDE'>NLW</scene></td></tr>
[[Category: James, L.I]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3k26|3k26]]</td></tr>
[[Category: Frye, S.V]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ttw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttw OCA], [http://pdbe.org/5ttw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ttw RCSB], [http://www.ebi.ac.uk/pdbsum/5ttw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttw ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/EED_HUMAN EED_HUMAN]] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<ref>PMID:9584199</ref> <ref>PMID:10581039</ref> <ref>PMID:14532106</ref> <ref>PMID:15385962</ref> <ref>PMID:15231737</ref> <ref>PMID:15225548</ref> <ref>PMID:16357870</ref> <ref>PMID:18285464</ref> <ref>PMID:20974918</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Barnash, K D]]
[[Category: Bountra, C]]
[[Category: Brown, P J]]
[[Category: Edwards, A M]]
[[Category: Frye, S V]]
[[Category: James, L I]]
[[Category: The, J]]
[[Category: The, J]]
[[Category: Bountra, C]]
[[Category: Eed peptide inhibitor]]
[[Category: Arrowsmith, C.H]]
[[Category: Transcription regulator-inhibitor complex]]
[[Category: Brown, P.J]]
[[Category: Wd40]]
[[Category: Barnash, K.D]]
[[Category: Edwards, A.M]]
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