1qa6: Difference between revisions
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'''CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX''' | '''CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX''' | ||
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[[Category: Gittis, A G.]] | [[Category: Gittis, A G.]] | ||
[[Category: Lattman, E E.]] | [[Category: Lattman, E E.]] | ||
[[Category: | [[Category: Antibiotic binding]] | ||
[[Category: | [[Category: Minor groove binding]] | ||
[[Category: | [[Category: Ribosomal rna]] | ||
[[Category: | [[Category: Tertiary structur,e rna-protein interaction]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:03:33 2008'' | |||
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Revision as of 03:03, 3 May 2008
CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX
Overview
The structure of a highly conserved complex between a 58-nucleotide domain of large subunit ribosomal RNA and the RNA-binding domain of ribosomal protein L11 has been solved at 2.8 angstrom resolution. It reveals a precisely folded RNA structure that is stabilized by extensive tertiary contacts and contains an unusually large core of stacked bases. A bulge loop base from one hairpin of the RNA is intercalated into the distorted major groove of another helix; the protein locks this tertiary interaction into place by binding to the intercalated base from the minor groove side. This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome.
About this Structure
1QA6 is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a conserved ribosomal protein-RNA complex., Conn GL, Draper DE, Lattman EE, Gittis AG, Science. 1999 May 14;284(5417):1171-4. PMID:10325228 Page seeded by OCA on Sat May 3 06:03:33 2008
