1qas: Difference between revisions
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'''1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1''' | '''1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1''' | ||
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[[Category: Grobler, J A.]] | [[Category: Grobler, J A.]] | ||
[[Category: Hurley, J H.]] | [[Category: Hurley, J H.]] | ||
[[Category: | [[Category: Calcium-binding]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: | [[Category: Lipid degradation]] | ||
[[Category: | [[Category: Transducer]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:04:38 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 03:04, 3 May 2008
1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1
Overview
The structure of the PH-domain truncated core of rat phosphoinositide-specific phospholipase C-delta 1 has been determined at 2.4 A resolution and compared to the structure previously determined in a different crystal form. The stereochemical relationship between the EF, catalytic, and C2 domains is essentially identical. The Ca2+ analogue Sm3+ binds at two sites between the jaws of the C2 domain. Sm3+ binding ejects three lysine residues which bridge the gap between the jaws and occupy the Ca2+ site in the apoenzyme, triggering a conformational change in the jaws. The distal sections of the C2 jaws move apart, opening the mouth by 9 A and creating a gap large enough to bind a phospholipid headgroup.
About this Structure
1QAS is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
C2 domain conformational changes in phospholipase C-delta 1., Grobler JA, Essen LO, Williams RL, Hurley JH, Nat Struct Biol. 1996 Sep;3(9):788-95. PMID:8784353 Page seeded by OCA on Sat May 3 06:04:38 2008
