1qmc: Difference between revisions
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'''C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES''' | '''C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES''' | ||
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[[Category: Plasterk, R H.A.]] | [[Category: Plasterk, R H.A.]] | ||
[[Category: Sprangers, R.]] | [[Category: Sprangers, R.]] | ||
[[Category: | [[Category: Aid]] | ||
[[Category: | [[Category: Dna-binding protein]] | ||
[[Category: | [[Category: Integrase]] | ||
[[Category: | [[Category: Polyprotein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:26:51 2008'' | |||
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Revision as of 03:26, 3 May 2008
C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES
Overview
The structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase has been refined using nuclear magnetic resonance spectroscopy. The protein is a dimer in solution and shows a well-defined dimer interface. The folding topology of the monomer consists of a five-stranded beta-barrel that resembles that of Src homology 3 domains. Compared with our previously reported structure, the structure is now defined far better. The final 42 structures display a back-bone root mean square deviation versus the average of 0.46 A. Correlation of the structure with recent mutagenesis studies suggests two possible models for DNA binding. Proteins 1999;36:556-564.
About this Structure
1QMC is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase., Eijkelenboom AP, Sprangers R, Hard K, Puras Lutzke RA, Plasterk RH, Boelens R, Kaptein R, Proteins. 1999 Sep 1;36(4):556-64. PMID:10450096 Page seeded by OCA on Sat May 3 06:26:51 2008
