5u4x: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
m Protected "5u4x" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5u4x is ON HOLD
==Coactivator-associated arginine methyltransferase 1==
 
<StructureSection load='5u4x' size='340' side='right' caption='[[5u4x]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
Authors: DONG, A., ZENG, H., WALKER, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5u4x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U4X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U4X FirstGlance]. <br>
Description: Coactivator-associated arginine methyltransferase 1
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7VM:N-METHYL-N-[(2-{1-[2-(METHYLAMINO)ETHYL]PIPERIDIN-4-YL}PYRIDIN-4-YL)METHYL]-3-PHENOXYBENZAMIDE'>7VM</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_I_protein_arginine_methyltransferase Type I protein arginine methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.319 2.1.1.319] </span></td></tr>
[[Category: Dong, A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u4x OCA], [http://pdbe.org/5u4x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u4x RCSB], [http://www.ebi.ac.uk/pdbsum/5u4x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u4x ProSAT]</span></td></tr>
[[Category: Zeng, H]]
</table>
[[Category: Walker, J.R]]
== Function ==
[[Category: Wu, H]]
[[http://www.uniprot.org/uniprot/CARM1_HUMAN CARM1_HUMAN]] Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.<ref>PMID:16497732</ref> <ref>PMID:19405910</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Type I protein arginine methyltransferase]]
[[Category: Arrowsmith, C H]]
[[Category: BROWN, P J]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
[[Category: Arrowsmith, C.H]]
[[Category: DONG, A]]
[[Category: Brown, P.J]]
[[Category: Edwards, A M]]
[[Category: Edwards, A.M]]
[[Category: Structural genomic]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: STONE, H]]
[[Category: Saikatendu, K S]]
[[Category: WALKER, J R]]
[[Category: WU, H]]
[[Category: ZENG, H]]
[[Category: Carm1]]
[[Category: Methyltransferase]]
[[Category: Sgc]]
[[Category: Tp-064]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/5u4x"