1qz7: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1qz7.gif|left|200px]] | [[Image:1qz7.gif|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1qz7", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
or leave the SCENE parameter empty for the default display. | |||
--> | |||
{{STRUCTURE_1qz7| PDB=1qz7 | SCENE= }} | |||
| | |||
| | |||
}} | |||
'''Beta-catenin binding domain of Axin in complex with beta-catenin''' | '''Beta-catenin binding domain of Axin in complex with beta-catenin''' | ||
| Line 33: | Line 30: | ||
[[Category: Xing, Y.]] | [[Category: Xing, Y.]] | ||
[[Category: Xu, W.]] | [[Category: Xu, W.]] | ||
[[Category: | [[Category: Axin]] | ||
[[Category: | [[Category: Beta-catenin]] | ||
[[Category: | [[Category: Protein-protein complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:53:02 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 03:53, 3 May 2008
Beta-catenin binding domain of Axin in complex with beta-catenin
Overview
The "beta-catenin destruction complex" is central to canonical Wnt/beta-catenin signaling. The scaffolding protein Axin and the tumor suppressor adenomatous polyposis coli protein (APC) are critical components of this complex, required for rapid beta-catenin turnover. We determined the crystal structure of a complex between beta-catenin and the beta-catenin-binding domain of Axin (Axin-CBD). The Axin-CBD forms a helix that occupies the groove formed by the third and fourth armadillo repeats of beta-catenin and thus precludes the simultaneous binding of other beta-catenin partners in this region. Our biochemical studies demonstrate that, when phosphorylated, the 20-amino acid repeat region of APC competes with Axin for binding to beta-catenin. We propose that a key function of APC in the beta-catenin destruction complex is to remove phosphorylated beta-catenin product from the active site.
Disease
Known disease associated with this structure: Colorectal cancer OMIM:[116806], Hepatoblastoma OMIM:[116806], Hepatocellular carcinoma OMIM:[116806], Ovarian carcinoma, endometrioid type OMIM:[116806], Pilomatricoma OMIM:[116806]
About this Structure
1QZ7 is a Protein complex structure of sequences from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA.
Reference
Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex., Xing Y, Clements WK, Kimelman D, Xu W, Genes Dev. 2003 Nov 15;17(22):2753-64. Epub 2003 Nov 4. PMID:14600025 Page seeded by OCA on Sat May 3 06:53:02 2008
