5hrj: Difference between revisions
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==Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163== | |||
<StructureSection load='5hrj' size='340' side='right' caption='[[5hrj]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hrj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HRJ FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hrj OCA], [http://pdbe.org/5hrj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hrj RCSB], [http://www.ebi.ac.uk/pdbsum/5hrj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hrj ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/C163A_PIG C163A_PIG]] Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.<ref>PMID:14648288</ref> After shedding, the soluble form (sCD163) may play an anti-inflammatory role. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Jiang, L]] | |||
[[Category: Li, R]] | |||
[[Category: Ma, H]] | [[Category: Ma, H]] | ||
[[Category: Qiao, S]] | [[Category: Qiao, S]] | ||
[[Category: Zhang, G]] | [[Category: Zhang, G]] | ||
[[Category: Balbes nmr]] | |||
[[Category: Cd163]] | |||
[[Category: Endocytosis]] | |||
[[Category: Prrsv]] | |||
[[Category: Srcr]] | |||
Revision as of 15:59, 20 October 2017
Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163
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