5ubk: Difference between revisions
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==Inactive S1A/N269D-cpPvdQ mutant in complex with the pyoverdine precursor PVDIq reveals a specific binding pocket for the D-Tyr of this substrate== | |||
<StructureSection load='5ubk' size='340' side='right' caption='[[5ubk]], [[Resolution|resolution]] 2.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ubk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UBK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=83M:N-[(1R)-1-{(6S)-6-[(2-AMINO-2-OXOETHYL)CARBAMOYL]-1,4,5,6-TETRAHYDROPYRIMIDIN-2-YL}-2-(4-HYDROXYPHENYL)ETHYL]-N~2~-TETRADECANOYL-L-GLUTAMINE'>83M</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ubl|5ubl]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyl-homoserine-lactone_acylase Acyl-homoserine-lactone acylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.97 3.5.1.97] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ubk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubk OCA], [http://pdbe.org/5ubk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ubk RCSB], [http://www.ebi.ac.uk/pdbsum/5ubk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE]] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Acyl-homoserine-lactone acylase]] | |||
[[Category: Catlin, D]] | |||
[[Category: Clevenger, K]] | |||
[[Category: Fast, W]] | |||
[[Category: Liu, D]] | |||
[[Category: Mascarenhas, R]] | |||
[[Category: Wu, R]] | |||
[[Category: Cppvdq]] | |||
[[Category: Cppvdq s1a/269d]] | |||
[[Category: Hydrolase]] | |||
[[Category: Pyoverdine precursor]] | |||
[[Category: Substrate:mutant pvdq complex]] | |||
Revision as of 09:42, 11 March 2017
Inactive S1A/N269D-cpPvdQ mutant in complex with the pyoverdine precursor PVDIq reveals a specific binding pocket for the D-Tyr of this substrate
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