5wte: Difference between revisions

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'''Unreleased structure'''


The entry 5wte is ON HOLD  until Paper Publication
==Cryo-EM structure for Hepatitis A virus full particle==
<StructureSection load='5wte' size='340' side='right' caption='[[5wte]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5wte]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WTE FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wtf|5wtf]], [[5wth|5wth]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wte OCA], [http://pdbe.org/5wte PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wte RCSB], [http://www.ebi.ac.uk/pdbsum/5wte PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wte ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Hepatitis A virus (HAV) infects approximately 1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific monoclonal antibody, R10, which neutralizes HAV infection by blocking attachment to the host cell. High-resolution cryo-EM structures of HAV full and empty particles and of the complex of HAV with R10 Fab reveal the atomic details of antibody binding and point to a receptor recognition site at the pentamer interface. These results, together with our observation that the R10 Fab destabilizes the capsid, suggest the use of a receptor mimic mechanism to neutralize virus infection, providing new opportunities for therapeutic intervention.


Authors:  
Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.,Wang X, Zhu L, Dang M, Hu Z, Gao Q, Yuan S, Sun Y, Zhang B, Ren J, Kotecha A, Walter TS, Wang J, Fry EE, Stuart DI, Rao Z Proc Natl Acad Sci U S A. 2017 Jan 10. pii: 201616502. doi:, 10.1073/pnas.1616502114. PMID:28074040<ref>PMID:28074040</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 5wte" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dang, M]]
[[Category: Fry, E E]]
[[Category: Gao, Q]]
[[Category: Hu, Z]]
[[Category: Rao, Z]]
[[Category: Ren, J]]
[[Category: Stuart, D I]]
[[Category: Sun, Y]]
[[Category: Walter, T S]]
[[Category: Wang, J]]
[[Category: Wang, X]]
[[Category: Yuan, S]]
[[Category: Zhang, B]]
[[Category: Zhu, L]]
[[Category: Hav]]
[[Category: Neutralizing mechanism]]
[[Category: Receptor recognition]]
[[Category: Viral entry]]
[[Category: Virus]]
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