Geranylgeranyl transferase

spinqualitylabelsall models Structure of rat geranylgeranyl transferase type 2 subunitsα (magenta) and β (cyan) complex with geranylgeranyl pyrophosphate, Zn+2 (grey) and Ca+2 (green) ions (PDB code 3dst). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Geranylgeranyl transferase type 1 (GGT1) adds a 20-carbon isoprenoid group called geranylgeranyl (GG) to the C-terminal of proteins containg the CAAX motif (Cysteine, Aliphatic, Aliphatic, any amino acid). Geranylgeranyl transferase type 2 (GGT2) adds 2 GG groups to C-terminal cysteine residue of a protein. The addition of the hydrophobic prenyl group causes the proteins to become membrane-associated. Relevance GGT2 inhibitors block bone resorption and induces myeloma cell apoptosis. Structural highlights The active site with bound geranylgeranyl pyrophosphate contains a Zn+2 atom. Water molecules shown as red spheres.

3D structures of eranylgeranyl transferase

Updated on 31-March-2019

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• Geranylgeranyl transferase type 1
  • 1s64 – rGGT1 α+β subunits + inhibitor - rat
    
  • 1n4p – rGGT1 α+β subunits + GGPP
    
  • 1n4s, 1n4r – rGGT1 α+β subunits + GGPP + peptide-GG containing CAAX
    
  • 1tnb, 1tno, 1tnu, 1tny, 1tnz, 1n4q – rGGT1 α+β subunits + GGPP analog + peptide containing CAAX
    
  • 3dra – GGT1 α+β subunits + GGPP – Candida albicans
    
• Geranylgeranyl transferase type 2
  • 1dce – rGGT2 α+β subunits – rat
    
  • 3dss – rGGT2 α+β subunits
    
• Geranylgeranyl transferase type 2 complex
  • 3c72, 3pz1, 3pz3, 4ehm, 4gts, 4gtt, 4gtv – rGGT2 α+β subunits + inhibitor
    
  • 3hxb, 3hxc, 3hxd, 3hxe, 3hxf – rGGT2 α (mutant) +β subunits + inhibitor
    
  • 1ltx – rGGT α+β subunits + tetra-alanine + Rab escort protein + farnesyl
    
  • 3dst – rGGT2 α+β subunits + GGPP
    
  • 3dsu – rGGT2 α+β subunits + farnesyl-PP
    
  • 3dsv, 3dsw, 3dsx – rGGT2 α+β subunits + GG
    
  • 3pz2 – rGGT2 α+β subunits + GGPP + inhibitor
    

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