BRCA

spinqualitylabelsall models Human BRCA1 BRCT1 and BRCT2 domains (turqouis) complex with phosphopeptide (red) (PDB code 3coj) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function BRCA1 and BRCA2 or breast cancer type 1 susceptibility protein are tumor suppressors which help repair damaged DNA. For more details see RING Finger Domain of BRCA1 and BARD1 Heterodimer. Disease Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers. Structural highlights The phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains. These domains contain most of the mutations seen in BRCA1.

3D structures of BRCA1

RING Finger Domain of BRCA1 and BARD1 Heterodimer, 4y18, 4y2g, 4u4a, 4jlu, 4ifi, 4igk, 3k0h, 3k0k, 3coj, 1y98, 1t15, 1t29, 1t2v - hBRCA1 BRCT1 domain + peptide inhibitor - human
3pxa, 3pxb, 3pxc, 3pxd, 3pxe, 3k15, 3k16 - hBRCA1 BRCT1 domain (mutant) + peptide inhibitor
1jnx - hBRCA1 BRCT domain
2ing, 1t2u, 1n5o - hBRCA1 BRCT1 domain (mutant)
1oqa - hBRCA1 BRCT-C domain - NMR
1l0b - BRCA1 BRCT domain - rat
2n9e - hBRCA1 SUMO-interacting motif + small ubiquitin-related modifier - NMR
4mkf, 4mkg - hBRCA1 SUMO-interacting motif - NMR
1jm7 - hBRCA1 Ring domain + BARD1 ring domian - NMR

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman