1rh7: Difference between revisions
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'''Crystal Structure of Resistin-like beta''' | '''Crystal Structure of Resistin-like beta''' | ||
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[[Category: Scherer, P E.]] | [[Category: Scherer, P E.]] | ||
[[Category: Shapiro, L.]] | [[Category: Shapiro, L.]] | ||
[[Category: | [[Category: Glucose uptake]] | ||
[[Category: | [[Category: Hormone]] | ||
[[Category: | [[Category: New york structural genomix research consortium]] | ||
[[Category: | [[Category: Nysgxrc]] | ||
[[Category: | [[Category: Protein structure initiative]] | ||
[[Category: | [[Category: Psi]] | ||
[[Category: | [[Category: Resistin/fizz family]] | ||
[[Category: | [[Category: Structural genomic]] | ||
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Revision as of 04:29, 3 May 2008
Crystal Structure of Resistin-like beta
Overview
Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and diabetes. Crystal structures of resistin and RELMbeta reveal an unusual multimeric structure. Each protomer comprises a carboxy-terminal disulfide-rich beta-sandwich "head" domain and an amino-terminal alpha-helical "tail" segment. The alpha-helical segments associate to form three-stranded coiled coils, and surface-exposed interchain disulfide linkages mediate the formation of tail-to-tail hexamers. Analysis of serum samples shows that resistin circulates in two distinct assembly states, likely corresponding to hexamers and trimers. Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in pancreatic-insulin clamp studies reveals substantially more potent effects on hepatic insulin sensitivity than those observed with wild-type resistin. This result suggests that processing of the intertrimer disulfide bonds may reflect an obligatory step toward activation.
About this Structure
1RH7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Disulfide-dependent multimeric assembly of resistin family hormones., Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L, Science. 2004 May 21;304(5674):1154-8. PMID:15155948 Page seeded by OCA on Sat May 3 07:29:40 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Mus musculus
- Single protein
- Burley, S K.
- NYSGXRC, New York Structural GenomiX Research Consortium.
- Patel, S D.
- Rajala, M W.
- Scherer, P E.
- Shapiro, L.
- Glucose uptake
- Hormone
- New york structural genomix research consortium
- Nysgxrc
- Protein structure initiative
- Psi
- Resistin/fizz family
- Structural genomic
