Methotrexate: Difference between revisions
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<StructureSection load='2w3m' size='450' side='right' scene='42/420816/Cv/2' caption=''> | <StructureSection load='2w3m' size='450' side='right' scene='42/420816/Cv/2' caption=''> | ||
[[Methotrexate]], formerly known as amethopterin, is a drug that is used in the competitive inhibition of [[Dihydrofolate reductase]], resulting in decreased synthesis of dTTP and diminished cellular replication. The antimetabolic nature of methotrexate is most effective against the most rapidly dividing cells, making this drug useful in [[Cancer]] [[Pharmaceutical Drugs|treatment]], and various autoimmune diseases<ref>Methotrexate. (n.d.). UW Department of Orthopaedics and Sports Medicine - Patient Care. Retrieved March 10, 2011, from http://www.orthop.washington.edu/PatientCare/OurServices/Arthritis/Articles/Methotrexate.aspx </ref>. | [[Methotrexate]], formerly known as amethopterin, is a drug that is used in the competitive inhibition of [[Dihydrofolate reductase]], resulting in decreased synthesis of dTTP and diminished cellular replication. The antimetabolic nature of methotrexate is most effective against the most rapidly dividing cells, making this drug useful in [[Cancer]] [[Pharmaceutical Drugs|treatment]], and various autoimmune diseases<ref>Methotrexate. (n.d.). UW Department of Orthopaedics and Sports Medicine - Patient Care. Retrieved March 10, 2011, from http://www.orthop.washington.edu/PatientCare/OurServices/Arthritis/Articles/Methotrexate.aspx </ref>. | ||
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==Chemical Properties== | ==Chemical Properties== | ||
Chemical Formula: C<sub>20</sub>H<sub>22</sub>N<sub>8</sub>O<sub>5</sub> | Chemical Formula: C<sub>20</sub>H<sub>22</sub>N<sub>8</sub>O<sub>5</sub> | ||
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Half-life: 3–15 hours<ref>Medical Pharmacology Topics. (n.d.). Angelfire: Welcome to Angelfire. Retrieved March 10, 2011, from http://www.angelfire.com/sc3/toxchick/medpharm/medpharm65.html</ref> | Half-life: 3–15 hours<ref>Medical Pharmacology Topics. (n.d.). Angelfire: Welcome to Angelfire. Retrieved March 10, 2011, from http://www.angelfire.com/sc3/toxchick/medpharm/medpharm65.html</ref> | ||
== History == | == History == | ||
