ERGIC-53: Difference between revisions
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<StructureSection load='4gky' size='350' side='right' caption='Human ERGIC-53 carbohydrate recognition domain complex with mannose (stick model), glycerol and Ca+2 ion (green) (PDB code [[4gky]])' scene='74/748868/Cv/1'> | <StructureSection load='4gky' size='350' side='right' caption='Human ERGIC-53 carbohydrate recognition domain complex with mannose (stick model), glycerol and Ca+2 ion (green) (PDB code [[4gky]])' scene='74/748868/Cv/1'> | ||
== Function == | == Function == | ||
'''ER-Golgi Intermediate Compartment-53 (ERGIC-53)''' is a transmembrane protein which acts as a receptor of glycoproteins and transports them from the ER to ER-Golgi Intermediate Compartment and Golgi<ref>PMID:19609866</ref>. | '''ER-Golgi Intermediate Compartment-53 (ERGIC-53)''' is a transmembrane protein which acts as a receptor of glycoproteins and transports them from the ER to ER-Golgi Intermediate Compartment and Golgi<ref>PMID:19609866</ref>. | ||
== Relevance == | == Relevance == | ||
Some ER storage diseases have relationship with ERGIC-53. ERGIC-53 is required for the propagation of arenavirus, coronavirus and filovirus<ref>PMID:24237698</ref>. | Some ER storage diseases have relationship with ERGIC-53. ERGIC-53 is required for the propagation of arenavirus, coronavirus and filovirus<ref>PMID:24237698</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. The <scene name='74/748868/Cv/2'>mannose-binding pocket of ERGIC-53 contains a Ca+2 ion as well</scene><ref>PMID:23709226</ref>. | ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. The <scene name='74/748868/Cv/2'>mannose-binding pocket of ERGIC-53 contains a Ca+2 ion as well</scene><ref>PMID:23709226</ref>. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of ERGIC-53== | ==3D structures of ERGIC-53== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
