5u0c: Difference between revisions

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'''Unreleased structure'''
{{Large structure}}
 
==Structure of Zika virus NS5 RNA polymerase domain==
The entry 5u0c is ON HOLD  until Paper Publication
<StructureSection load='5u0c' size='340' side='right' caption='[[5u0c]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 
== Structural highlights ==
Authors: Zhao, B., Du, F.
<table><tr><td colspan='2'>[[5u0c]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U0C FirstGlance]. <br>
 
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
Description: Structure of Zika virus NS5 RNA polymerase domain
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u0c OCA], [http://pdbe.org/5u0c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u0c RCSB], [http://www.ebi.ac.uk/pdbsum/5u0c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u0c ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
{{Large structure}}
== Function ==
[[http://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV]] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763]  prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763]  Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763]  Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763]  Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732]  Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763]  Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763]  Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]
__TOC__
</StructureSection>
[[Category: Du, F]]
[[Category: Zhao, B]]
[[Category: Zhao, B]]
[[Category: Du, F]]
[[Category: Rna polymerase]]
[[Category: Transferase]]
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