5ubw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ubw is ~~ON HOLD~~ ~~until Paper Publication~~

==Structure of catalytic domain of Ssel==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5ubw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UBW FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ubw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubw OCA], [http://pdbe.org/5ubw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ubw RCSB], [http://www.ebi.ac.uk/pdbsum/5ubw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubw ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SSEL_SALTY SSEL_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells. Specifically hydrolyzes mono- and polyubiquitin substrates in vitro with a preference for 'Lys-63'-linked ubiquitin chains, suggesting that it interferes with a signaling pathway rather than inhibiting proteasomal-dependent degradation of its targets. Does not possess desumoylating activity. Is required for the Salmonella-induced delayed cytotoxicity in macrophages and full virulence. Is not required for intracellular bacterial replication.<ref>PMID:17158898</ref> <ref>PMID:17360673</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Das, C]]

[[Category: Shrestha, R]]

[[Category: Deubiquitinase]]

[[Category: Hydrolase]]

[[Category: Salmonella]]

[[Category: Uch family]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ubw is ON HOLD  until Paper Publication
+==Structure of catalytic domain of Ssel==
+<StructureSection load='5ubw' size='340' side='right' caption='[[5ubw]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ubw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UBW FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ubw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubw OCA], [http://pdbe.org/5ubw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ubw RCSB], [http://www.ebi.ac.uk/pdbsum/5ubw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SSEL_SALTY SSEL_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells. Specifically hydrolyzes mono- and polyubiquitin substrates in vitro with a preference for 'Lys-63'-linked ubiquitin chains, suggesting that it interferes with a signaling pathway rather than inhibiting proteasomal-dependent degradation of its targets. Does not possess desumoylating activity. Is required for the Salmonella-induced delayed cytotoxicity in macrophages and full virulence. Is not required for intracellular bacterial replication.<ref>PMID:17158898</ref> <ref>PMID:17360673</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Das, C]]
+[[Category: Shrestha, R]]
+[[Category: Deubiquitinase]]
+[[Category: Hydrolase]]
+[[Category: Salmonella]]
+[[Category: Uch family]]